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Trius Therapeutics, Inc. (TSRX) Message Board

  • cahi55 cahi55 Jun 26, 2013 4:04 PM Flag

    cempra is cutting in!

    Cempra has been garnering all the attention of late

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    • they have only phase 2 results on TAKSTA™ (CEM-102, sodium fusidate) comparable to linezolid...not as far along nor effective as TED. Their Solithromycin, in phase III for community acquired pneumonia, may have major toxicity issues as was pointed out earlier by EM438

    • They are different, yet similar... There is room for both.

      Sentiment: Hold

      • 2 Replies to results75
      • em438@rocketmail.com em438 Jun 26, 2013 10:54 PM Flag

        as for fusidic acid...Fucidin Tablets and Suspension occasionally cause liver upsets, which can produce jaundice (yellowing of the skin and the whites of the eyes). This condition will almost always get better after the patient finishes taking Fucidin Tablets or Suspension. Other related side-effects include dark urine and lighter-than-usual feces. These, too, should normalize when the course of treatment is completed and It has been reported on August 8, 2008, that the Irish Medicines Board is investigating the death of a 59-year-old Irish man who developed rhabdomyolysis after combining Lipitor and Fusidic Acid, and three similar cases.[22] In August, 2011, the UK's Medicines and Healthcare products Regulatory Agency issued a Drug Safety Update warning that "Systemic fusidic acid (Fucidin) should not be given with statins because of a risk of serious and potentially fatal rhabdomyolysis. Correct if I am wrong but doesn't just about everyone over 50 take a statin...I stick with Tedizolid.

      • em438@rocketmail.com em438 Jun 26, 2013 10:40 PM Flag

        solithromycin operates in the pneumonia and STD space...while TZD operates in the MRSA, Pneumonia, and Bacteremia space and is farther ahead. besides solithro will get yanked just like it cousin ketek for liver toxicity...my skin crawls just looking at that structure.

 
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