There is reason to have "concerns" about any company you choose to invest in as well as the marketplace itself at any given time. But the bottom line to me is the need for and quality of Trius' products couldn't be more obvious. The rest is just noise.
Believe it or not, and at a restrictive timetable for SEC "insiders" to buy or sell, these insiders need money like the rest of us and exercise that right. These sales were not due to pending bad news. I have been involved in researching biotech companies and have authored several chemistry "white" papers on different drugs and I have never seen a drug that was this much of a "slam-dunk" going into the NDA filing. Never.
this last month there was only one exercised option sell at $4 on a 20,000 share block. Nice bit of profit return on exercised options but had he held longer if they weren't expired he could have made more. All the rest of the small sales were automatic 10b5-1 plans previously in place. Taxes on exercised options are part of the motivation in sales.
It takes money to keep Ms Alfalski's hydrangea bushes so perky and big. They are the envy of many from Hodge Podge Lodge right up to Pugwash Junction. So far the SP has been in an upward trajectory during these automatic sales. No big concern here.