ThermalOverload>>>> I feel very good that you sold your calls and that you and Kingmidastouch.....are on your way to other stocks. The sooner the frustrated stock holders move on so that the building of a new basis around $9.00 a share with new stock holders the better off the long term investors will be. <<<<<<< Thermal, does holding since 1994 qualify as a long term holder? This garbage company has yielded less than a savings pass book account in this time period. My only salvation has been that this was a very minor holding in my portfolio. I only blame myself for not getting out at the top. I was naive enough to believe that these scientists could actually transition this company to an ongoing real business. This management achieved the ultimate goal of attaining FDA approval of what should have been a blockbuster drug. They then proceeded to make three tragic blunders. The biggest blunder was choosing an incompetant marketing firm, Block Drug. Let's be honest. Would you choose a firm whose main products they distributed included such product stalwarts as Diaper rash ointment, Goody's headache powder (when's the last time anyone here used "headache powder' for a headache?), Nature's Remedy Laxative, & the ultimate product...R&C Lice Treatment, to market a state of the art treatment product to be sold to professional dentists & periodontists? The next biggest blunder was the ill-advised issuance of the convertible preferred debt. If you don't believe that was a blunder, I'll go back & retrieve the Street.com article on this method of rasing cash, assuming it was needed in the first place. The absolute refusal to co-operate with the analyst community is inexcusable. Is it a result of the rediculous agreement with Block, or just a supercillious attitude of management? Either case, the blame lies squarely at Urheim's feet. Despite the negative vote against management that was 20 X the prior years vote, this management is entrenched & scoff at the minority shareholders. Nothing will change until real business managers are in place. I don't see that happenning. How big would a company like Cisco be today if Len Begozian (sp?)& former wife, (the original founders) were still running the company? These scientists at Atrix are not gonna cut it. That's my opinion. fwiw.
I don't either - and we're getting out of my comfort level! Lipophilic I know would imply of course fat (not too important here) and nerve membranes (maybe helpful). The A.a. seems to concentrate in connective tissue, and I really don't know the lipid content there - its mostly collagen fibers, but beyond that, I'm not sure.
As far as the level of bactermia - I'll bet the levels are reduced with Atridox, but again I really question the clinical significance. Even the once established need for antibiotic premedication for patients with heart murmurs is changing, and I suspect will be nearly eliminated when the new guidelines come out (except for a few specific cases). I'm not saying its not important - I really don't know for sure - but in light of the fact that patients self-induce a small but transient bacteremia every time they eat, I'd be surprised if it was significant, and that may be why ATRX isn't releasing it. Just a guess..
You know, I was supposed to be done with all this stuff when I finished my boards! You are at least making me think! I'm real curious to know if some of the hotshots at ATRX (esp. Dr Garrett) read this stuff - if I see them at the AGD meeting I may ask 'em.
Doxy is highly lipophilic and is readily absorbed into surrounding tissue. (However, I'm not sure if that translates into all tissue types or what the effective distance from point of origin is). Atiridox has done studies suggesting the absorbed doxy maintains lethal dosage levels for in excess of 30 days.
ATRX is currently conducting studies to determine levels of bacteremia caused by SRP vs. Atridox. Rumor mill indicates preliminary results are startling in favor Atridox. Why doesn't ATRX release this info?
I'm sure SRP causes higher levels initally, but what do you think will be more significant over a long period - you eat (and hopefully floss and brush) a lot more than you have SRP done. Rest assured, the body is constantly assaulted by bacteria, and can handle the challenge for the most part!
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Donald, FYI, you can also cause a bacteremia (bacteria in the blood stream) by the simple everyday acts of eating, brushing, and flossing? So what are you going to do? Not eat? >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Yes, but what are the relative amounts of bacteremia caused by these things you mention? Don't you think that something as invasive as SRP would cause an awful lot more bacteremia than eating, brushing or flossing?
No, I don't have any study saying that SRP causes more bacteria in the bloodstream than any of those things, but wouldn't common sense tell us that it probably does?