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Inovio Pharmaceuticals, Inc. Message Board

  • john_m_us john_m_us May 20, 2013 7:19 PM Flag

    INO Dna vaccines do not need to be refrigerated

    INO Dna vaccines do not need to be refrigerated. This is a major point that most people here do not seem to know. This will extend the reach of these vaccines to the 3rd world where refrigeration is not available. This is a big game changer. This would make organizations that purchase and make vaccines available to these areas more than willing to pay a bit more for one of our vaccines. I THINK, but do not know this will be true of all DNA vaccines...

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    • DNA vaccines are stable at a wider range of temperatures, reducing the need for costly and logistically challenging cold-delivery chains that can prevent treatments getting to where they are most needed, particularly in the developing world.
      DNA vaccines are easier to manipulate than many conventional vaccine elements, and genomic technology can make bespoke sequences (which are delivered as DNA loops called plasmids) quickly to tackle rapidly emerging threats, such as food poisoning outbreaks, or local variants of established diseases.

      Culturing infectious agents for vaccines requires expensive quarantine facilities that can never be 100% failsafe – accidental (or even malicious) release into the environment is always a possibility.

      • 2 Replies to martha.varias
      • That is a very important point. The stability at room temperature allows broader shipping advantages. However, if the shipper gets too careless, they may cause accelerated degeneration. Stability studies are very routine. The temperatures studied are -80 degrees C (Revco freezer), -20 F (refrigerator freezer), 2-8 degrees C (refrigerator temperature), room temperature (~68-72 degrees F), elevated temperature (~78-82 degrees F), around 94-98 degrees F and 45 degrees C which is pasteurization temperature for many liquids over an extended period of time. The goal is to compare the denaturation/degeneration curves at the different temperatures and determine how long a preparation remains unaltered. We did that for the blood substitue Oxyglobin originally approved by Biopure Corp. It was stable at room temperature fo 6 months. But it had additives to eliminate all oxygen from the bag prior to final fill.

        But if a vaccine is stable at room temperature for 6 months, that is great. Is there accelerated stability data published on some of these vaccines? Big part of DD.

        Sentiment: Strong Buy

      • thanX John for the help.

        Sentiment: Strong Buy

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