INO-1400 will address 85% of hTERT related cancers. What is the largest cancer state/type in that remaining 15%? I am curious if INO is targeting that as well.
If you or anyone have a (legitimate) scientific question. send me an email. Just say "INO question" in the subject line or something like that. I don't come here too often anymore. This stock is gonna do what its gonna do (go up), and I don't need to wade through 1000s of negative bull crud posts to see that.
Glad you responded to this post Postgost67. Thank you and don't wade through the poo, just post every so often with you few on INO so we can see your point of view. Your posts are greatly valued by those of us who are here to partake in a honest and civil discourse. You will fined that we come to you for the kind of interaction you might hope to find.
Perhaps you don't need our views to confirm your opinion of INO but there are a lot of newbes here now who are hungry for confirmation. Please come see us more often.
OK, so this is a bit of a touchy subject, and one where the company isn't 100% accurate on. This is not any fault of their own, but its more a misquote of the scientific literature that has been repeated (and changed along the way) so many times that it became a new truth… Sort of like when we played telephone when we were kids. Background: Human telomerase reverse transcriptase (hTERT) is an enzyme that adds telomeres, or short repeats of DNA to the end of chromosomes after a cell divides (through a process that I have not studies, so I don’t know the exact mechanism). This is done because every time a cell divides or replicates, it has to make a copy of its DNA for the next cell. Each time it does that, a little portion of the extra telomere end DNA gets cut out. If telomeres get too short, cells die, even when cells are dividing. This occurs because DNA repair mechanisms get activated, but the repair mechanisms aren’t able to fix the DNA (you can’t fix not having enough DNA), the DNA present isn’t enough to make a full genome, so as a mechanism to protect the integrity of its genome (and prevent cancer from developing) these cells die by programmed cell death (or apoptosis). This gene is activated when we are embryos, but shut down soon after, and then we have our telomeres for life in all somatic cells. This is a mechanism of cellular senescence and one reason some people believe we age and die. Gonad telomerase is supposed to be active throughout life, and dedicated stem and progenitor cells (such as in the intestine and hematopoietic stem cells) do express telomerase as well. T cells and B cells (which replicate very quickly after spotting an infection) also can reactivate telomerase when needed.
postgost67, this is fascinating science, reminds me of a 60 minute broadcast, something like 10 years ago, Google it, called "The Fountain of Youth" where 3 Biochemists discovered almost the same thing you described and they were awarded the Nobel Prize for that. They wrote that every time our cells divided that they lost a part of the last or the tail end of the chromosome's address. This, according to what they discovered was being caused by the ultra violet suns' rays hitting our genes and that was why we aged. They did a human trial, according to the report and the results were that 70 year olds were in the study and they started to show remarkable changes in the elasticity of skin, hair color started changing to like when they were younger. There was one bad side affect that you can hear from the report.
All I know for sure is that Inovio is doing work that will change life as we know it and furthermore the "Big Boys" are taking note, scrambling to lay claim to this science.
Good luck to everyone who believes in our company.
Sentiment: Strong Buy
I have crawled through this post 4 times now and is starting to sink in. I want to try to put it in layman's terms but I don't wish to embarrass myself. I have not even started to read your other post but I have my homework for tomorrow . For now . my brain is starting to grasp it.
Incredible detailed response PG. I feel like i should pay you a consulting fee for such a thorough response. Lol. One of the reasons I missed you on your brief hiatus from the board. Suffice it to say, some if the largest markets will be addressed by this "universal cancer treatment." INO-1400 has my attention for sure.
Thanks posgost67, I'd like to see Inovio create a perfect synthetic DNA cell that our cells can then use to copy every time like a perfect xerox telomere copy... an exact duplicate reproduced every time. That would mean we will grow younger and live to 350 years or longer. Our bodies can repair defective organs, skin, eyes, ears, everything... very interesting.
Posgost - your answers in this thread are incredibly informative (and well written). I am guessing you also have teaching experience from the way you can clearly explain something so complex to a simpleton like me!
So there are mutations in several of the telomerase genes that occur in humans. These include dyskeratosis congenital (mutation in dyskerin or TERC, two regulatory components of the functional complex), and these patients develop cancer at an early age (oral cancer, myelodysplastic syndrome, and leukemia) but die of lethal aplastic anemia when their bone marrow fails. Also aplastic anemia, is another disease that is thought to be caused by inactivation/mutation of telomerase (remember above where I said hematopoietic stem cells have activated TERT expression).