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Peregrine Pharmaceuticals, Inc. Message Board

  • adman_q8 adman_q8 Jul 21, 2014 7:53 PM Flag

    Hope PPHM give us some news on Melanoma combo to know...the truth of Bavi

    Kim Sherman was in bad shape a year ago after a lemon-sized melanoma tumor in her pelvis stopped responding to standard targeted therapy. By late June 2013, the pain from the mass pressing on her hamstring became so bad she could hardly sleep, walk, or even sit down.

    Then she joined a trial on an experimental drug from Bristol-Myers Squibb Co. designed to boost the immune system against her tumor when used in combination with the company’s existing immune enhancing drug Yervoy. Within three weeks the pain started to subside, and within three months later the tumor disappeared. Her doctor at Yale Cancer Center in New Haven may stop therapy entirely in a few weeks, she said.

    “I was ecstatic. I had the best possible result,” said Sherman, a 48-year-old mother of three from Buchanan, New York. “This is a pretty remarkable drug combination.”

    At the American Society of Clinical Oncology meeting in Chicago, results like this are raising hopes that new immune system-boosting medicines can produce long survival in numerous advanced tumors, at least for those who respond to the drugs.

    In Sherman’s trial, 79 percent of an initial group of 53 patients who received the experimental medicine nivolumab combined with Yervoy were still alive after two years, a better result than is seen with existing drugs for advanced melanoma.

    In another study of 411 advanced melanoma patients who got Merck & Co.’s drug, called MK-3475, 62 percent were alive 18 months after starting treatment, according to results being released at the meeting. Merck has already applied for U.S. Food and Drug Administration marketing approval based on the results, with a decision

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    • 16:06 $ 1.6201 High 53,627 AH some one either covered or took real advantage of the dip here. I would like to believe that covering is soon to under way. Someone had to sell to this order unless it was mkt swapping helping each over trying to cover or someone knows there is something on the way from the co soon. You don't just buy 53,627 out of the blue and such an odd number. Your guess is as good as mine. I like it though.

0.90+0.02(+2.27%)Feb 12 4:00 PMEST