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Aeterna Zentaris Inc. Message Board

  • ving0000 ving0000 Mar 10, 2012 11:51 AM Flag

    Exam results next exit !

    1) We have p results for phase 2, where both pfs and os are in the range that implies a more than 99 percent chance of them beeing reproduced, and not caused by randomness alone.

    2) Perifosine has performed with statistical significance in about 10 different tumors

    3)Ph 3 has passed t/f test by dsmb

    4) Phase 3 has endured for so long, that if history is a reliable guide all but very very few placebo patients can possibly be alive around March 15, dictating that survivors in the perifosine arm has prevented the trial from having reached the 360th event.

    5) correcting for end skewed recruitment, only makes a tiny dent in OS figure.

    6) Drop outs due to tox are either followed up for event count, or beeing counted as an event by the time of drug termination. According to general procedures.
    Tox terminants are therefore not confounders in trial extension.

    http://www.trialsjournal.com/content/3/1/4

    In light of this I find it extremely unlikely that exam results will be nothing but outstanding, poising perifosine way above all current targeted drugs in both efficacy and non-toxicity.

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