I haven't listened to the presentation made today that is available on the website due to time constraints but they did present at the JP Morgan Healthcare conference today at 10 am. I merely attributed the drop to the overall market drop, now I am wondering if their goals released today and announced cash runway into 2015 were too ambitious and too costly? They plan to spend 170-180M this year and lose the same amount. Anyone else care to weigh in? I'm not a big holder at 500 shares.