Fri, Aug 1, 2014, 4:51 AM EDT - U.S. Markets open in 4 hrs 39 mins

Recent

% | $
Click the to save as a favorite.

Oramed Pharmaceuticals Inc. Message Board

  • rrtzrealmd rrtzrealmd Dec 24, 2013 12:38 PM Flag

    Words of advice...

    ...always get suspicious when a biotech claims "success" with ANYTHING since a biotech's definition of "success" is probably a LOT broader than what most people accept...note that the PR manages to neglect any mention of pertinent NUMBERS -- how many patients, statistics, etc...

    ...second, watch the UNITS!...back in April, ORMP published "Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study" in which they CLAIMED success with patients taking 8 MG of insulin (ORMD-0801) THREE time a day...and it appears that was given ALONG WITH the patients standard subcutaneous injections...

    ...well, 8 MG of insulin represents about 200 UNITS of regular insulin...that's a total of SIX HUNDRED units a day!...a typical type 1 diabetic needs less than 1 unit per kg or less than 80 mg a day on average...so ORMP was adding SIX HUNDRED units ON TOP of the patients usual dose -- ie increasing their dose by 7-8 TIMES!...

    ...and the thing is, simply squirting 200 U of regular insulin into a diabetic's mouth could have the same effect since absorption from the oral mucosa would likely achieve serum levels similar to ORMD-0801...

    ...finally, be highly suspicious of ANYTHING coming from an Israeli company -- I'm not being anti-semitic when I say I don't recall Israel coming up with many medical breakthroughs...

    SortNewest  |  Oldest  |  Most Replied Expand all replies
    • ...gee, looks like I was right, huh?...HAW!!!...

    • Actually- on a % basis-since Israel; is in the top three in start ups on our exchanges and have been successful and honest on both thats a biased statement on your part
      Look at Xoma who recently placed stock at 5,25 after being hire and it made new highs recently

    • I would not believe the results, but oral med is better than injection, and liver monitor of blood glucose is better than pancreas and beta cells and isle of langerhans, do your due diligence, I think they have a better product than insulin, and 20 years of research, and EU approval.

      • 2 Replies to w.bennett18
      • ...geez!...if ignorance is bliss, then you must be one really happy camper!...the liver does NOT "tell" the pancreas to do ANYTHING...

        ...beta cells in the pancreas respond to elevated glucose levels and release insulin proportionally which, in turn, stimulates fat and various other tissues to absorb glucose, consequently reducing blood glucose levels...

        ...on the other hand, alpha cells in the pancreas respond when glucose levels drop below threshold and they produce glucagon which stimulates the live to breakdown glycogen to glucose and which also stimulates gluconeogenesis -- conversion of amino acids into glucose -- which result in raising blood glucose...

        ...also, oramed's pill is decidedly NOT less than what is required by injection!...insulin is USUALLY measured in "units" and 1 IU is equivalent to 0.0347 mg of human insulin ...a typical pre-meal injection for a type 1 diabetic would be about ONE mg of insulin...

        ...got that?..now .ORMD-0801 has EIGHT MILLIGRAMS of insulin in EACH pill!...in other words, each pill has EIGHT TIMES as much insulin as a typical injected dose...

        ....and in the one study Oramed published, each patient received that pill THREE TIMES a day...and apparently that was ON TOP OF the patient's usual subcutaneous doses...

        ...I can't find anything published that shows the effect of ORMD-0801 when used alone on patients -- is such data published anywhere?...

        ....like I pointed out previously, I suspect if someone measured the effect of simply swishing 8 mg of injectable insulin around patients' mouths, they would see about the same effect as with Oramed's product...I seriously doubt Oramed has anything that will ever be worth marketing...

      • The liver tells the pancreas to release insulin. In diabetics the pancreas either can not produce insulin or is exhausted as example. Orameds pill contains insulin. Near 30 years research. Noble price winner, top ex pfizer exec on board. Presented results on several conferences. Peer reviewed. I agree there are questionmarks such as bioavailability which is claimed a company secret. Also the dosage is unclear. It could be that they can give enough insulin so the liver can monitor and release as needed?

    • The number of patients and control has been communicated a couple of times. think it was 30 patients. Google

 
ORMP
8.3256-0.2844(-3.30%)Jul 31 3:58 PMEDT

Trending Tickers

i
Trending Tickers features significant U.S. stocks showing the most dramatic increase in user interest in Yahoo Finance in the previous hour over historic norms. The list is limited to those equities which trade at least 100,000 shares on an average day and have a market cap of more than $300 million.
Tesla Motors, Inc.
NasdaqGSThu, Jul 31, 2014 4:00 PM EDT
eHealth, Inc.
NasdaqGSThu, Jul 31, 2014 3:59 PM EDT