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  • zibbedibee zibbedibee Jul 10, 2014 4:06 PM Flag

    Tufts Trials Purpose?

    Probably known to many here, but it was a surprise for me when I learned that all the ACT Tufts Dog trials are injecting HUMAN es-msc. That's correct, isnt it?

    Which leads me to the questions, are they really trying to find a treatment for dogs/animals with the intent to make this a vet product if successful? I mean, can human stem cells actually do something good for a dog? Isnt the DNA too different?
    Or are they merely trying to find more data about how an organism can react to cells from another donor, amplified in this study as they are even cells from a different species? With the intention to get more insight about treatments for humans...

    Just wondering. Human cells pumped into a we might do it the other way round.
    Any infos out there or opinions?
    Now back to politics.

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    • I got a hold of the Webinar, really interesting stuff. Thanks for pointing this out, Clown.
      What I take away from that, as a bloody Layman is that they are not meaning for the Stemcells to differentiate into Special cells (tissue etc), because these would in fact be human tissue, in a dog!, but they are trying to exploit other therapeutic attributes of stem cells, chemical and nano-partical effects to influence and stimulate the function of other dog cells. And for this it doesnt seem to make a difference that they are human stem cells.
      I can see how findings and results of this study could help with applying such treatments for the same kind of diseases in humans later on.

      If I look at it from the business side for ACT, it has been speculated that the Tuft trials could result in revenue for ACT with Vet-Treatment Therapies, earlier than any revenue from the AMD/SMD treatments, kind of in order to help finance the human trial progression.
      Somehow I doubt that, imo. I think that if they were serious about making a stem cell treatment product for pets as early as possible, they would be better off using animal stem cells, as this is
      a) not controversial at all, in contrast to using human embryo cells to save a cat and
      b) well....less risky to show yet unknown side effects

      So yeah, I think the goal is to get treatments for humans in the long run, and I dont expect any revenue from animal treatments anytime soon.

      An interesting afterthought maybe, if human stem cells can treat certain diseases in a dog, can a dog stem cell do the same for a human? oO

    • Zibbe, I don't think the Hes-Msc injections being given the dogs at Tufts Vet Clinic Stem Cell Therapies has any effect on their DNA, as the DNA has already been mapped out during conception. But ACT did use the Hes-Msc injections to cure Multiple Sclerosis (MS) in mice. There was a press release on June 8, 2014 regarding this. So yes, I guess, you can use human stem cells to treat dogs without changing their DNA. But we Probably need Dr Lanza to explain this in more detail this for us.

    • There is a webinar available online given by the lead investigator Dr. Hoffman at Tufts. He said the indications they chose (7 of them) were chosen because the diseases have human parallels. Their goal is to not only develop treatments for animals but also to lay the groundwork to launch human INDs based on the results. He feels that their approach of treating animals (peoples real pets) with naturally occurring diseases provides better indications of efficacy than does testing on rodents that are engineered to have particular diseases. So even though they are performing vet trials they are very focused on the human application of the therapy.

      Just think, if human cells work well in dogs they'll probably even work better in humans.