Takeda Saved Japan's Population After WWII from Beriberi Outbreak
Beriberi was a widespread neurodegenerative scourge in parts of the world after WWII when food was in short supply. In japan, it was much worse because the polished rice was stripped of thiamin and the raw fish (sushi) which was a dietary staple contains a thiaminase that breaks down thiamin. Takeda went on a crash course with Nishin Flour Milling Company to fortify foods with a novel compounds, a fat soluble thiamin, as thiamin tetrahydrofurfuryl disulfide. They saved an entire generation of Japanese people with this effort. The patent has long since expired, but it's still useful for various neuropathies, Thank you Takeda.