One Case Against PH20- Interferes w Remyelination via Oligodendrocyte (OPC) Maturation Inhibition- Prevents Stroke Repair
OLIGODENDROGENESIS AFTER CEREBRAL ISCHAEMIA
AND TRAUMATIC BRAIN INJURY
Zheng Gang Zhang,1 Michael Chopp1,2
1. Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
2. Department of Physics, Oakland University, Rochester, Michigan, USA
Disclosure: This work was supported by National Institutes of Health Grants RO1 NS075156 (ZGZ) and
AG037506 (MC). The content is solely the responsibility of the authors and does not necessarily represent
the official view of the National Institutes of Health.
Received: 07.10.13 Accepted: 25.10.13
Citation: EMJ Neurol. 2013;1:26-31
New oligodendrocytes derived from non-myelinating
oligodendrocyte progenitor cells (OPCs) are required
to form myelin sheaths for sprouting axons during
brain repair processes after brain injury.
Inhibition of PH20 Hyaluronidase May Effectively Promote Remyelination in Multiple Sclerosis Lesions
Posted January 9, 2014
Larry Sherman, Ph.D., Oregon Health & Science University, and Paul Weigel, Ph.D., Oklahoma Health Sciences Center
Interestingly, HA digestion products formed by PH20, but not the others, inhibited OPC maturation and thus prevented remyelination.
PH20 is not the only anti-tumpr Hyaluronidase- HYAL1 and HYAL2 are as well in vivo.
HYAL1 and HYAL2 Inhibit Tumour Growth In Vivo but Not In Vitro
Jingfeng Li equal contributor,
Vera N. Senchenko,
The results suggest that the expression of either gene has led to inhibition of tumour growth in vivo without noticeable effect on growth in vitro. HYAL1 and HYAL2 thus differ in this aspect from other tumour suppressors like P53 or RASSF1A that inhibit growth both in vitro and in vivo. Targeting the microenvironment of cancer cells is one of the most promising venues of cancer therapeutics. As major hyaluronidases in human cells, HYAL1 and HYAL2 may control intercellular interactions and microenvironment of tumour cells providing excellent targets for cancer treatment.
So, the same medication that increases clotting and resulting stroke also blocks it's repair. Do YOU think pH20 is the ONLY Hyalurionidase? Is That your level of knowledge? Figures- same low level with which you made up Hyaluronan screening before pH2 peg-gem-abrax studies (Doesn't Exist).