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I think that what you have missed is the following:1. Topiramate is already an approved drug, and it is widely prescribed and used, and it has a long history since 1996.2. The incidences of cleft lip were for dosages that are 2 to 4 times higher than what is contained in the highest dose of Qnexa.3. The UK study scientist stated that "you can not draw any conclusions from their study because the sample size was too small and the Confidence Interval was too high.