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Synta Pharmaceuticals Corp. Message Board

  • plagioclase2002 plagioclase2002 Nov 7, 2012 10:53 AM Flag

    Hsp 90 Inhibitor

    The only other small company,that I am aware of, working on second generation Hsp-90 is Synta(snta) . You may find the transcript of yesterdays conference call of interest.

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    • Astex Pharmaceuticals has one too...AT13387, but not as far in trials as ganetespib.
      So there you have it, the remaining Hsp90 inhibitors:

      Synta (GANETESPIB)
      Infinity (Retaspimycin, as stated below)
      Vernalis/Novartis (AUY922)
      Astex (AT13387)
      Debiopharm (Debio 0932)

      The others have fallen by the wayside. Vernalis' will crumble due to ocular toxicity. Astex's has shown to be less effective than ganetespib. That leaves Infinity's, Synta's, and maybe Debiopharm's in the game, and we are much farther ahead than theirs. Do your own research. Hsp90 inhibition is the real deal, and we likely have the MOST potent drug with the LEAST side effects.

    • Vernalis (partnered with Novartis) also has hsp90 inhibitor, AUY922, in phase 2 trials. Trials are still continuing, despite ocular toxicity.... I think it's treading on thin ice.
      We have a GOLD mine here in ganetespib.

      Sentiment: Strong Buy

    • Actually, not true.
      Infinity Pharmaceuticals (INFI) has an Hsp90 inhibitor-- Retaspimycin HCL. Theirs targets similar cancer patient populations as Synta's. But their market cap is double that of Synta's!!! (in part, they do have a second very promising drug, IPI-145). Synta is still quite UNDER-valued, and has a lot of room to run. Look at Infinity's yearly chart. I predict that will be our chart as well in 2013....

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