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  • ColeThornton ColeThornton Jul 27, 2005 6:58 PM Flag

    Back to Back, 52 week HIGHS!!!

    SCI is up

    10% in 1 month
    20% in 3 months
    30% in 1 year
    250% in the last 3 years

    It's hit new 52 week highs on the last two consecutive trading sessions! I might finally have an idea on the candle DrippingRoast was talking about. In the movie, The Right Stuff, Alan Shepard said "Light this candle!". The way this baby has gone up recently... I just wonder.

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      July 2005
      Flu viruses mix it up
      Tom Simonite

      Study of gene swapping adds to pandemic fears.

      The flu jab sometimes doesn't work, thanks to viruses that mix and match their genes.

      A map of the evolution of flu viruses has revealed just how frequently they swap genes with each other.

      The result renews fears that a nasty virus such as avian influenza could pick up a gene from a human flu virus that makes it more transmissible, leading to a possible pandemic. And it highlights how easy it is for a strain of flu to evolve for which we don't have a vaccine.

      The most serious causes of human flu, called A viruses, have the ability to swap genes when they infect the same person. This reassortment can produce strains that are more problematic because they differ from the ones our immune systems have learnt to recognize.

      To investigate how often this happens, researchers looked at the published genome sequences of 156 flu strains that circulated in New York state between 1999 and 2004.

      Swap shop

      They constructed family trees that show how these viruses slowly evolved over time. And they discovered at least four instances where a virus had picked up a gene from another virus through reassortment. Edward Holmes, a biologist at the Centre for Infectious Disease Dynamics at Pennsylvania State University, University Park, and colleagues report the results in PLoS Biology1.

      In one of these instances the gene swap resulted in a particularly nasty strain that struck New York in the winter of 2003-04. This 'Fujian' strain was produced when a virus that was common the previous year picked up a gene from a relatively harmless strain, which had been around for some years but infected very few people.

      The gene was for a protein that the virus uses to bind to cells it is going to infect. The version the dominant strain picked up was very different to the one it had before, catching people's immune systems, and vaccines, unawares.

      The researchers say they found a wider variety of strains circulating at any one time than expected, and more instances of gene swapping.

      "Multiple lineages coexist at the same time and place, and the key thing is that they are reassorting and doing so quite frequently," says Holmes.

      Clearer picture

      Alan Hay, director of the World Health Organization's UK flu centre says the work will "give us a better idea of the variation and extent of recombination".

      Hay adds that flu researchers already had a good idea of how reassortment happens, from studies that tracked specific genes for surface proteins. But Holmes's research goes beyond this by using whole genome sequences, he says, giving a clearer picture of how often this happens.

      "I think these analyses will help us understand in detail the evolution of the influenza virus, taking into account more than just these genes," Hay says.

      Holmes says that further studies investigating the genome sequences of bird-flu viruses could help us understand whether recombination is as just common in those.

      Some researchers are now trying to create recombinant strains in the lab, using bird and human viruses, to see what a pandemic virus might look like and how easily it might form.

    • Thanks for your reply!

    • Cole thank you for your words..I don't have a reliable internet connection but you can google cup and handle and learn the basics.
      Don't worry about the arcane stuff that's for fine tuning your bets.You can make money using basic technicals.I'll be back to the boards regularly nexxt Thursday or so.. have fun bye

    • It's the only rational choice. Nothing much has changed with regard to novel flus since 1918, except Tamiflu and vaccine, and we don't have the latter at the moment:

      "The effect of the influenza epidemic was so severe that the average life span in the US was depressed by 10 years. The influenza virus had a profound virulence, with a mortality rate at 2.5% compared to the previous influenza epidemics, which were less than 0.1%. The death rate for 15 to 34-year-olds of influenza and pneumonia were 20 times higher in 1918 than in previous years (Taubenberger). People were struck with illness on the street and died rapid deaths. One anectode shared of 1918 was of four women playing bridge together late into the night. Overnight, three of the women died from influenza (Hoagg). Others told stories of people on their way to work suddenly developing the flu and dying within hours (Henig). One physician writes that patients with seemingly ordinary influenza would rapidly "develop the most viscous type of pneumonia that has ever been seen" and later when cyanosis appeared in the patients, "it is simply a struggle for air until they suffocate," (Grist, 1979). Another physician recalls that the influenza patients "died struggling to clear their airways of a blood-tinged froth that sometimes gushed from their nose and mouth," (Starr, 1976). The physicians of the time were helpless against this powerful agent of influenza."

    • I have already checked it out, and I have already sent an email to a friend whose brother is a doctor.
      I really appreciate all your help, I'm a belt "&" suspenders kinda guy.

    • It's not a vaccine. It's a drug that inhibits the replication of the virus once you are exposed, and which can keep you from getting the virus while you are being exposed.

      Read the information:

      I suppose you can get it online from one of those pharmacies - I don't know much about them.

    • When we have gotten the flu vaccine in the past, the dr gave us a shot. Why is this one from the pharmacy? Is it in pill format? Some of these online pharmacies seem awfully anxious to sell drugs. Maybe on of them will do it with their "on-line" doctor.

    • I got it last fall when our 'normal' vaccine production broke down and there was no flu vaccine for anyone under the age of 65. As did my kids - they're grown - and wife.

      Not a state secret. I have been paying attention to this bug for quite awhile. The writing was on the wall even back then, though it has progressed much faster than I expected.

      I don't know, tell him you are taking the family to Australia. They're having a raging 'normal' flu epidemic at the moment.

    • "You have to get a prescription from a doctor. Then you can get it at your local pharmacy or via an online pharmacy. Lie if you have to."
      I wonder what story would work to get a prescription for every member of my family. If I tell them we have symptoms, we might be quarantined by the CDC or WHO.(exagerating a bit, but you get the idea) How did you do it?(I understand if this is classified)
      You don't think a letter of recommendation from brother_humv will do the trick?

    • You have to get a prescription from a doctor. Then you can get it at your local pharmacy or via an online pharmacy.

      Lie if you have to.

      And then there's always this:

      I wouldn't rely on it though. Try Pinot Noir.

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