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Marina Biotech, Inc. Message Board

  • moose_catcher moose_catcher Nov 21, 2012 3:13 PM Flag

    Another Patent Issued

    Anthony Marina Patent Issued yesterday: 8,314,227

    Hydroxymethyl substituted RNA oligonucleotides and RNA complexes

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    • I like how this patent describes ways to reduce off target effects, enhance gene silencing, etc. These RNA complexes are designed to improve many attributes. Search the USPTO site with the patent number provided above and read the description of the invention.

    • I googed for a new patent and it didn't come up. Does it read similar to or drastically different to the 2008 patent?, under the same topic?

      Sentiment: Buy

      • 2 Replies to cmatulka71386
      • Wengel? Right? I looked at but am not technical enough to see the difference. Moose will.

        SUMMARY

        The present invention provides RNA complexes with one or more hydroxymethyl substituted monomers incorporated into an RNA strand to be used in relation to RNA-guided gene regulation or gene analysis, in particular RNA interference. Thus, it is an object of the present invention to provide RNA complexes, which have reduced off target effects as compared to the RNA complexes typically used. Another object is to provide RNA complexes which induce a reduced interferon response. Still another object is to provide RNA complexes with improved properties with regard to stability towards enzymatic degradation in cell cultures or in vivo. Still another object is to provide RNA complexes that display enhanced gene regulatory function, e.g. gene silencing effect, in cell cultures or in vivo, relative to the unmodified RNA complexes. Yet further objects are to provide RNA complexes that are targeted towards specific organs or tissue, and that are capable of penetrating the cell membrane. The present invention also provides monomers suitable for incorporation of hydroxymethyl substituted monomers into oligonucleotides and methods for their synthesis.

      • Wengel right? I am not technical enough to tell the difference.

        SUMMARY

        The present invention provides RNA complexes with one or more hydroxymethyl substituted monomers incorporated into an RNA strand to be used in relation to RNA-guided gene regulation or gene analysis, in particular RNA interference. Thus, it is an object of the present invention to provide RNA complexes, which have reduced off target effects as compared to the RNA complexes typically used. Another object is to provide RNA complexes which induce a reduced interferon response. Still another object is to provide RNA complexes with improved properties with regard to stability towards enzymatic degradation in cell cultures or in vivo. Still another object is to provide RNA complexes that display enhanced gene regulatory function, e.g. gene silencing effect, in cell cultures or in vivo, relative to the unmodified RNA complexes. Yet further objects are to provide RNA complexes that are targeted towards specific organs or tissue, and that are capable of penetrating the cell membrane. The present invention also provides monomers suitable for incorporation of hydroxymethyl substituted monomers into oligonucleotides and methods for their synthesis.

 
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