that says, "Not for patients who have compromised immune systems or are taking immuno-suppressant medications."? Could it be that those that got PML had compromised immune systems? Was anything ever said about that as it relates to the PML victims that took Tysabri along with other drugs?
It`s amazing reg. the track you`re on with patient NO.1
As you stated, quite a few people probably have missed your posts!
Why don`t you repost them on European mornings
when our YMB isn`t so crowded?
I agree with you.
Even eating too much food and drinking too much water can kill.
Let's look at the facts and the way I am thinking about Tysabri:
1. Tysabri got a fast approval by the FDA before. That means this drug is extremely effective to treat MS.
2. BIIB/ELN newest study founds no new case for PML. And they can screen the PML before it is too late. That means even the combo method might be allowed to comeback.
Does this make sense?
Are you insane? Or just ignorant?
EVERY drg has side effects and millions are prescribed every day.
Ty is far safer than any of the other MS drugs, with better efficacy.
How many deaths has aspirin caused, not to mention Remicade, Humira?
This whole fiasco is the biggest tempest in a teapot I've ever seen.
You people thinking one or two deaths means a drug is forever tainted deserve to lose all your money.
>> Has this been discussed here before?
Yes a bit last week.
740438, 740505, 740516 (& repsonses by nangasimon) Re: Why MRIs - no blood test/nangasimon [ that's the only real discussion to my knowledge]
nangasimon hadn't noticed the OCB negative bit when reading the NEJM articles, but then I hadn't either when I read them first.
I was too focussed on finding signs of immunesuppression to notice (many other will have missed it as well).
737889, 737915, 737954, 737959 "Patients at risk, what is the pattern?" [ that's just me ranting away ]
>> Could it be that those that got PML had compromised immune systems? Was anything ever said about that as it relates to the PML victims that took Tysabri along with other drugs?
Patient #3 certainly was severely immunecompromised from 1998 to the end of 2003.
His TLC was below 1200 (infact his highest was 1000 and lows were 300). A TLC of 1200 corresponds to a CD4 of circa 200, or AIDS level.
So this patient had a CD4 less than 200 all the time from 1998 until the end of 2003 and at various times had a CD4 of ca 50 (TLC 300).
CD4 at 100 is the level were high risk for PML is imminent, 200 is significant risk for PML.
We have to little info about patient #1 or #2 to know their immunesystem status. They both were on a combo with Avonex though.