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Alnylam Pharmaceuticals, Inc. Message Board

  • rnai_inv rnai_inv Mar 23, 2012 10:58 AM Flag

    PCSK9 results

    Among subjects receiving REGN727, there were no discontinuations because of adverse events. REGN727 significantly lowered LDL cholesterol levels in all the studies. In the multiple-dose study, REGN727 doses of 50, 100, and 150 mg reduced measured LDL cholesterol levels in the combined atorvastatin-treated populations to 77.5 mg per deciliter (2.00 mmol per liter), 61.3 mg per deciliter (1.59 mmol per liter), and 53.8 mg per deciliter (1.39 mmol per liter), for a difference in the change from baseline of โˆ’39.2, โˆ’53.7, and โˆ’61.0 percentage points, respectively, as compared with placebo (P<0.001 for all comparisons).


    In three phase 1 trials, a monoclonal antibody to PCSK9 significantly reduced LDL cholesterol levels in healthy volunteers and in subjects with familial or nonfamilial hypercholesterolemia.

    ALNY needs to show better results. No wonder they are looking to partner their PSCK9 program.

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