Well a few lessons emerging here. First, stock analysts are not good at science. This applies to those who could see no promise a year ago and those who see this is a proven technology today. Second, no brokerage ever says sell when a company hits their target and will certainly never say their analysis was wrong. Third, it is very ahrd to resist the psychology of more gains ahead because as a long my persistence has paid off and I am being rewarded. Have to go back and review some charts from 1998 to 2001 in stocks like INCY to keep my perspective. Going to take my initial risk capital off the table here and book a gain on that; ride with bthe houses money and hope my beleife in this company continues to work out. That would be very good for society, less good for me after a sale of part of my position.