<<As used herein, a "wound-healing effective amount" of a composition containing T.beta.4 or a T.beta.4 isoform for use in wound healing is defined as that amount that is effective in promoting tissue regeneration and repair. The "wound-healing effective amount" may be the therapeutically effective amount. Diseases, disorders or ailments possibly modulated by T.beta.4 or a T.beta.4 isoform include tissue repair subsequent to traumatic injuries or conditions including arthritis, osteoporosis and other musculo-skeletal disorders, burns, ulcers and other skin lesions, neurological and nerve disease and cardiovascular diseases including ischemia and atherosclerosis. Other potential tissues which can be treated by the methods and compositions of the invention include epidermal, eye, uro-genital, gastro-intestinal, cardiovascular, muscle, connective, and neural tissues. The term "induce", "induction" or "effect" as used herein, refers to the activation, stimulation, enhancement, initiation and/or maintenance of cellular mechanisms or processes necessary for the formation of a tissue or a portion thereof, repair process or tissue development as described herein.