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Novavax, Inc. Message Board

  • birdyvax birdyvax Dec 10, 2013 9:04 PM Flag

    Here's what's so alarming about the New Tamiflu Resistant Strain of H7N9

    Usually when an influenza virus undergoes a "gain of function", it becomes less lethal.
    Not so with the New H7N9 Strain. It is just a lethal as before.

    Gain of function = mutation.

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    • "Here's what's so alarming about the New Tamiflu Resistant Strain of H7N9"

      Besides of course...
      - 20% mortality rate
      - Drug resistant
      - Birds don't get sick...they just keep spreading the virus.
      - It's very difficult to test for in birds & humans.
      - The incubation period is only a few days... meaning it could spread like lightening.
      - No available vaccines
      - The epicenter is Shanghai, China's busiest & most traveled city.
      - The 2nd wave is on the way. (The 2nd wave of the 1918 Spanish/Bird Influenza was responsible for 90% of all deaths... The first wave was mild in comparison).
      - It's gaining function... Mutating.
      Other than that... No worries.

      • 2 Replies to birdyvax
      • LONDON (Reuters) - Scientists have found that a mutation in a new strain of bird flu infecting people in China can render it resistant to a key first-line treatment drug without limiting its ability to spread in mammals.

        The discovery means that unlike seasonal flu strains, which often become less transmissible when they develop resistance to drugs like Roche's Tamiflu, the new H7N9 bird flu does not lose any of its spreading potential with drug resistance.

        While this does not make H7N9 any more likely to develop into a human pandemic, researchers said it means doctors should be prudent in their use of anti-viral medicines to treat H7N9 cases, and consider using drugs other than Tamiflu, such as GlaxoSmithKline's Relenza, where possible.

        "It's important to emphasise that these H7N9 viruses seem to transmit fairly inefficiently overall," said Nicole Bouvier, who led the H7N9 study which was published in the journal Nature Communications on Tuesday.

        "But what was surprising about our study was that the drug-resistant virus was no less efficient than the drug-sensitive one. Usually what we see with influenza, is that resistance...also confers a fitness disadvantage on the virus."

        H7N9 bird flu emerged earlier this year in China and has infected at least 139 people so far in China, Taiwan and Hong Kong, killing 45 of them.

        Experts say there is no evidence as yet of any easy or sustained human-to-human transmission of H7N9. But an early scientific analysis of probable transmission of the new flu from person to person, published in August, gave the strongest proof yet that it can at times jump between people and so could potentially cause a human pandemic.

        A separate team of researchers in the United States said this week that while it is not impossible that H7N9 could become easily transmissible from person to person, it would need to undergo multiple mutations to do that. So scientists around the world are keeping a watchful eye, on alert for any sign the virus m

      • Gee unkie birdy can you tell us another bed time story? Im now wide AWAKE after that one. A good zombie tale post H7N9 outbreak would do it. LOL.

 
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