Unfortunate thing to happen with the death of a patient but since it is a rising dose MTD defining study they could potentially adjust the dosage with proof of safety margin??? Totally unclear at this point.
I am no expert here. However, there is NO indication of over dosage, It is much more the potential or probably deleterious effects of drug itself among certain patients or patients over time given a particular patient profile. Are there certain contradincators that in certain (few or many, note one is too many) in certain patients that can result in potential death. Never such a simple of a question of well we will just adjust dosage