In a study of Rapamicin as a treatment for TSC, researchers observed a major improvement regarding retardation related to autism. The researchers discovered sirolimus regulates one of the same proteins the TSC gene does, but in different parts of the body. They decided to treat mice three to six months old (adulthood in mice lifespans); this increased the autistic mice's intellect to about that of normal mice in as little as three days.
Alzheimer's in mice
Rapamicin reduced brain lesions and prevented the decline of performance in the water maze in mice with a mouse model of Alzheimer's. Because Rapamicin is already approved for other indications, it should be easy to start a clinical trial to see whether it works in humans.