- <15% response rate
- grade 3 & 4 side effects
- single arm trial of 65+ relapsed/refractory ALL patients (n=65)
- Phase 3 opened, but no patients enrolled
Ibrutinib (by time of filing for accelerated approval)
- 80%+ response
- some grade 2 and 3 diarrhea that can be managed
- single arm trial of 65+ treatment naive CLL patients
- multiple Phase 3 trials with 100+ patients enrolled
- 1000s patients on drug
The only difference in favor of Marbibo is the severity of the indication. Relapsed/refractory ALL patients have an expected survival measured in months - CLL years. The relapsed/refractory myeloma trial may end up proving to be the better filing.
I got on relatively late ($16.50) and of course I wish I had known about the stock earlier. I too don't know what is pushing it up other than true enthusiasm for the activity of the drug candidate: positive results.
Apparently the powers that be - the large scale investors - see something uniquely powerful in this drug candidate. Their technical advisors must be telling them that the results to date are top tier.
Oh I get the potential alright and this could be a monster. Having said that I've seen similar stories in the past and needless to say they don't always fulfill their potential. This one does look awfully good, however.
Say Smuckerboy1, do you live in Orrville, Ohio with the rest of the Smuckers? If so I like your blackberry jam.
I don't know what is levitating this stock but I'll take it. I've done all the prudent things like taking my own money out and then some. I have an average cost of 1.41 in my retirement account and 3.03 in my regular account so I'm just going to let it ride. It's been a wild ride but if promise becomes reality, this could be much bigger!
That's eerie blackspade -- I have major positions in both retirement and normal brokerage accounts, and these are nearly my cost bases as well. I wrote a few covered calls at 10 and 15 (long ago) to cash out 20-25%.
I will be tempted to sell a few more calls at 40 (November-January) if we get a couple of more pops like the one today. Good luck to you.