Justpaul, a point I was making is that this Arm D trial, if Adam is accurate about it, is not going to be the VRTX's homerun strategy. It is conducted for a comparison purpose. The stats from it will be used as a reference point against which 12+12 and 12+36 data will be measured. Of course, I don't downplay the importance of the correlation between early (and sustained) response and SVR12 of the fast-responding group. By itself it doesn't have a pps moving value unless it is very good or very poor. The Arm D fast-responding group doesn't even have a control group to measure against.