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Vertex Pharmaceuticals Incorporated Message Board

  • giguy_1999 giguy_1999 Dec 19, 2012 11:45 AM Flag

    You pumpers just don't get it BLACK BOX

    warning for a doctor means stay away. Far away.

    It's one thing if you are a cardiologist and use an antiarrythmic with no alternative.

    Here there are alternatives:

    1) do nothing
    2) liver biopsy and to reassess stage of inflammation and fibrosis
    3) use Victrellis
    4) wait for all oral regimens

    There will be absolutely no gastros using this drug with a Black Box warning.

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    • There are about 400 FDA approved drugs with black box warnings. Almost every day I administer drugs with black box warnings in my anesthesiology practice. Two commonly used black box warning drugs I use are succinylcholine (a muscle relaxant) and droperidol (used as an antiemetic). As clinicians, we weigh the risks and benefits of every medication we use and we are aware of the potential adverse events. We also know how to recognize those events and respond appropriately. Often, drugs with black box warnings are still the best choice.

      • 2 Replies to swhitemd50
      • Well said Dr. White. I would only add that many drugs have been associated with SJS/TEN with a higher incidence of this serious immune mediated drug reaction than has been observed with Incivek and they do not have black box warnings e.g. Bactrim. And as you note, these drugs continue to be used by clinicians, for appropriate conditions, observing for rashes, and discontinuing the offending drugs when they occur, and providing treatment to avoid the most serious complications. I would agree that the boxed warning involving Incivek may in fact slow sales further next year, but it's the next generation of IFN free treatment is really what people with Hep C are waiting for, and the net impact on Vertex of declining sales of Incivek next year will be offset by the increasing sales of Kalydeco in Europe, and the results of clinical trials in CF, RA (and other autoimmune diseases), influenza and IFN free hep C treatments which will show the real growth potential of this company.

        Sentiment: Strong Buy

      • Ridiculous analogy/comparison from anesthesia world to HCV world

        Succinylcholine is very, very rarely used in 2012- much safer induction agents, and Zofran is used as antiemetic, no one uses droperidol as antiemetic.

        There are alternatives to Incivek outlined above,

        Gastros will shy away from Incivek. Not worth the risk

        Hey, it's your money.

    • geez, did vrtx fire you? just go long and enjoy the ride up.

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