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Vertex Pharmaceuticals Incorporated Message Board

  • rojospan rojospan May 5, 2013 5:11 PM Flag

    Daclatasvir and VX 135 phase II


    starts in NewZealand. By the end of year they should have 24 week safey data on VX 135 on 60 patients.

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    • It is good news. Vertex is moving this combo ahead of other combos. Two blinded trials testing the 135+Riba combo started enrollment last November. In both trials the drugs were dosed only for 12 weeks. By now at least some of the participants are unblinded. This means that 135 is safe when dosed together with Riba for 12 weeks for some at least. Its efficacy should be as good as Sof if not better.

      If the 135+Dac combo is safe, it will be as good as Gilead's Sof+Led combo. Apparently drug-drug interactions are not a problem for this combo if listen to the last conference call. Dac has minimal sides. So, if 135 is safe, it is likely that the combo 135+Dac would be safe. The efficacy of the combo should be high.

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