Ocular toxicity related to cetuximab monotherapy in an advanced colorectal cancer patient.
Tonini G, Vincenzi B, Santini D, Olzi D, Lambiase A, Bonini S.
Quote from the paper:
The ocular toxicity is a newly described cetuximab-related toxicity, so the pathogenesis is not clearly established. Meibomian glands are the sebaceous glands of the eye that secrete tears, similar to the sweat gland apparatus of the skin. We hypothesize that cetuximab targets the EGFR-expressing cells of meibomian glands and may consequently lead to altered secretive function. GIUSEPPE TONINI BRUNO VINCENZI DANIELE SANTINI DIEGO OLZI ALESSANDRO LAMBIASE STEFANO BONINI
Thanks to finaid for this information.
With the number of patients treated and the very few number of patients who had this problem I doubt it will ever be used to determine which drug to take. Also at this time we probably do not know if 1 out of 3 or 4 thousand theracim patients might show up with the same problems.