Martinez didn't sell, he converted his options by paying the company 3.25 per share and now owns those 34583 shares. As stated in note #1(explanation of responses) of the form 4 filing, "The Director has no immediate intent to sell these newly acquired shares. ".
So BASICALLY, Martinez made a 100,000 dollar PLUS bet and is leaving another 130,000 dollars along with it on the table. This speak volumes in support of what the insiders in this company are picking up intuitively (or otherwise) regarding the outcome of the HEAT trials. They just wouldn't bother to stick their necks (and wallets) out if there was nothing to go on but hope.