How about just wiping out everyone from Morocco to Pakistan? Or at least Palestine to Iran.
What are we talking here, a few hundred million, tops?
We're not really using our nukes for anything anymore. Use 'em up & make work for a lot of people producing more.
Say, 10,000 warheads. That should leave the region with just its nomadic population. Scratch off all the cities & towns & start over again from the Neolithic level, pre-pottery. Bomb them back to the Stone Age, IOW.
The parts with oil, we move all illegal immigrants into.