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Seattle Genetics, Inc. Message Board

  • llabtechtwo llabtechtwo May 23, 2012 6:39 PM Flag

    I posted on cldx's board...

    but 32% ORR in highly expressed GPNMB!!!! Unbelievable this targeted cytotoxin did exactly what is was supposed too!! Just further validation of SGEN's technology!!! TOO COOL!!

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    • OK, let's see..............

      In heavily pre-treated triple negative patients who also expressed high levels of the target GPNMB the response rate was 36% versus 0% ( nilche / nada / nothing ) for the comparator drug treatments.

      OK, my eyebrows are raised.

      Good luck to all!

      Ricardo
      ------------

      Disclosure: Ricardo has a huge long term position in SGEN and a more modest holding of CLDX. The man is nuts, so you may want to consider you investment options on your own.

      • 1 Reply to Ricardouno
      • My eyebrows are raised because the sp tanked AH instead of shooting to the moon. May just be non serious investors taking profits. Hope it goes back to $5 again.

        Ricardo, are you familiar with study design? I'm a bit worried the GPNMB expression cutoff of 25%. If <25% of tumors have GPNMB, did they lump that into the 5%? IF they lumped all those with expression >15 or 20% could they have had a higher number of patients that actually responded? Just wondering if the 25% was set after data analysis and not prior.

 
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