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Seattle Genetics, Inc. Message Board

  • redhot47fla redhot47fla Nov 5, 2012 12:30 PM Flag

    Upcoming ASH studies: Adcetris + AVD achieves 92% complete remission rate in front-line Hodgkin and strong response in non-Hodg

    To be presented Dec. 10, 2012 re front-line Hodgkin:

    "At Cycle 2, 48 patients were evaluated by FDG-PET by central review; of these, all 22 ABVD and 24/26 AVD patients were PET negative. Of the 51 patients treated, 4 withdrew consent or were lost to follow-up prior to end of treatment (EOT) assessments. The remaining 47 patients had a 96% objective response rate: 21/22 ABVD patients (95%) and 23/25 AVD patients (92%) achieved CR at the end of frontline therapy, 1 AVD patient had PR (with further workup ongoing), 1 ABVD patient died of AEs (hyponatremia and pulmonary toxicity) prior to EOT, and 1 AVD patient had PD....

    "The very high CR rate seen in this cohort of advanced-stage HL patients compares favorably with historical controls and warrants comparison with standard therapy. A phase 3 study comparing brentuximab vedotin combined with AVD versus ABVD alone is planned."

    To be presented Dec. 9, 2012 re relapsed or refractory non-Hodgkin Lymphoma:

    "Of the 36 patients who have had a response assessment to date, 12 (33%) have achieved an objective response (5 CR, 7 partial remissions [PR]). The ORR for B-cell NHLs is 36% (9/25), and 27% (3/11) for mature T-/NK-cell NHLs. Thus far, responses are particularly noteworthy in DLBCL (excluding PMBL) where 7 of 15 patients (47%) have responded (3 CR, 4 PR), in AITL where 3 of 5 patients (60%) have responded (2 CR, 1 PR), and in grey zone lymphoma where 2 of 5 patients (40%) have achieved a PR. Median duration of response has not been reached. Of the 12 responding patients, 7 remain on treatment, 3 discontinued due to a patient decision (non-adverse event), and 2 due to adverse events of neutropenia (related) and pneumocystis jiroveci pneumonia (unrelated). CD30 expression levels for patients with a CR or PR were widely variable and ranged from

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    • blackmenrock Nov 5, 2012 2:53 PM Flag

      I traded back GM for SGEN today. The trade netted about $5 bucks, so it worked out. I still like GM also.
      I plan to stick around now but I still think it may show some weakness mid year 2013, Hopefully from a higher level.
      Still believe $100+ is in SGEN future.

    • The rest of the post (man, Yahoo has messed up these boards):

      ...CD30 expression levels for patients with a CR or PR were widely variable and ranged from

      • 1 Reply to redhot47fla
      • And, if you go to Seattle Genetics' website, you can see the ASH-related press release the company just posted, somewhat tardily:

        Seattle Genetics’ ASH 2012 Presentations Highlight ADCETRIS® and Demonstrate Leadership in the Development of Antibody-Drug Conjugates (ADCs)

        -Data Support Plans to Establish ADCETRIS as the Foundation of Therapy for a Broad Array of CD30-Positive Malignancies-

        -Company Announces Novel ADC Candidate SGN-CD33A and Encouraging ADC Collaborator Data Presentations-

        BOTHELL, Wash.--(BUSINESS WIRE)--Nov. 5, 2012-- Seattle Genetics, Inc. (Nasdaq:SGEN) today announced that more than a dozen abstracts, in addition to several collaborator abstracts, for both ADCETRIS (brentuximab vedotin) and investigational antibody-drug conjugates (ADCs) will be presented at the American Society of Hematology (ASH) Annual Meeting taking place in Atlanta, Georgia, December 8 – 11, 2012. ADCETRIS is an ADC directed to CD30, which is known to be expressed in Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), as well as in some types of cutaneous T-cell lymphoma (CTCL), B-cell lymphomas and mature T-cell lymphomas (MTCL). Seattle Genetics is broadly evaluating CD30 expression in many other cancer types. ADCETRIS is currently not approved for use in CTCL, B-cell lymphomas, and front-line treatment of HL or MTCL....

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