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ImmunoCellular Therapeutics, Ltd. Message Board

  • goodfellatattoo goodfellatattoo Jun 14, 2013 12:47 PM Flag

    what happens if event happens other than tumor related

    A friend and I were chating about the numbers and this came to mind...How does this figure into the numbers...what happens if someone dies in a car crash durning the study.(.god forbid of course) do they get added to the 64 deaths and if so will we know the results of exact cause of each event? I am still researching and will post a link if i find something.

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    • All events are included in the trial statistics. Be it control or vaccine patient. Cause is not factored in. :(

      • 1 Reply to daweasl652
      • Good question and dawease is correct! If only GBM related death were to be derived statistically, it would be labeled something like "Glioblastoma Multiforme Specific Survival." OS or Overall Survival is the standard. The differences are important to recognize in the following example. In a trial of 100 patients in each arm of a trial, the investigated treatment arm recognizes 15 fewer deaths due to the disease be investigated, but sees 12 more cases of death due to sudden MI, and 3 additional due to unidentifiable causes that were not seen in the control arm (such as auto accidents). In this case the there was no overall survival benefit, but 15% of the investigated arm did witness an improvement in disease survival. Hope this helps.

 
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