Hi Busted, I dunno about UK trials, but I do know from personal experience that U.S. trials patients must be incredibly ill to qualify. (The participants must have one foot in the grave so there's SOME morality in giving placebo to many of them in phase 3 & 4 trials.) Yet if they are just a tiny bit too ill, their fragility and prognosis is so bad it will doom the trial unfairly. So in effect, the criteria for qualifying is purposely designed to be incredibly narrow, almost knife-edged. Most of the patients you or I would consider good candidates for these trials turn out to be either too ill, or not ill enough. (That's why the U.S. cervical cancer clinical trial has got only 13 participants despite seeking a cohort of 67.) After all, I can guarantee you there are probably a few hundred U.S. women with stage 4b cervical cancer who would dearly love to get into our ADSX-HPV trial. Most cannot qualify simply because they are either too sick or not sick enough.