guestimates for LOG reduction in HCV viral titer. Please copy the list and add your name and the estimate (or correction to your previous estimate) if you want to participate.
I'm slightly lowering my guestimate, which i still consider optimistic (see posts 121912 & 91992 ). Recent article in Liver Transplant puts the population of HCV nonhepatic sources up to ~ 4% of the total viral production (these cells are not 'leaky' like hepatocytes, i.e. unlikely to get penetrated by PMO).
IMHO, plenty of wishful thinking and hype on this board but very little solid science. Worse, these few who understand the underlying biology are either doing poorly in mathematics or didn't bother to check the numbers. In my experience with speculative biotechs there is -- almost inevitably -- a stiff punishment for ignorance:) Anyhow, good luck!
exon_skipper: Undetectable (ie.meant PERFECT)
kajz777: 7.77 log reduction
mjrruby20000: 6log10 reduction
bionerd: (see post 125595) 4-5 log reduction
myboys2: 4.2log10 reduction
vskomarovsky 4.1 log
avi_killsh5n1: 4.0 log10 reduction
copphiggins 3.85 announce 4/12
Rwcscott: 3.8 Log Reduction, ann. 4/11/06
ermdme 3.77 log 10 reduction
southcascade 3.7 log
webofficenow: 3.5 log reduction
belowthefray: 3.4 (to the moon, Alice
redplate 3.3 log
InoKidding 3.267 log reduction
alexranaldi 3.14159 log reduction
csr1223: 3.12*Log reduction
steven_seagal_vphm: 3.1* LOG reduction.
prov719 >3.0 log
bionerd: see post # 104496 (around 3 LOG)
teachersr0ck: 3.0 LOG red. announced 4/7/06
skeptical_guy: 3.0 Log reduction, announce 4/29
timozark: 2.95 log
fiveburkesonly 2.8 Log reduction.
usagary1: 2.68*LOG reduction.
dnn15905: 2.63*LOG reduction.
alexanova7: 2.58*LOG reduction
powerfultoad 2.5 log
teebear00: 2.4*LOG reduction.
s2c_1999: 2.2 Log reduction
Klaus: 1.9*LOG reduction
notsoconfused: 0.7-1.7 LOG reduction (2x150 mg cohort)
ngrunes: < 1 log10 median reduction
thanks a lot that was very useful info !
i keep digging there -- amazing how much good stuff one can learn and how much time one can save following closely what the smart posters had uncovered already.
A long time ago stuv_xyz had interesting takes on SGMO. But those could be outdated if they're even still available to read.
Bordmup might have had a few posts. Also very dated.
There could be another more current poster with good contributions, but hard to find/remember with all the noise. I must admit, the people who work to make the board unreadable have done a good job over there. Try asking dressman about any other current posters as he has probably read more recent posts and might remember better.
i was away till yestarday and still haven't had a chance to read the posts on this (very prolific:) board, nor to examine AVI HCV data in detail -- will try to do that in the following days.
yep, thanks, i've realized that "fancy" is an interesting character.
Intersting you said that. I've been following SGMO for nearly 3 years. I have traded it a few times. And do plan to buy a chunk in the future. Dressman is a good read. Beware of fancy and his crew of 50 aliases.
Do you have any new thoughts on AVII?
"Another reason to take my profits at the time was that i had found a similar, but possibly more promising biotech stock.
What stock? "
SGMO is my best bet at present (definitely not a stock for people who are risk averse -- moreover, waiting a bit till the biotech selling subsides might be a clever move.)
I agree. PR is the second (after the science) catalyst to trigger market's reaction. To my mind comes the sign that one great Ukranian writer had in front of her, when she, on the turn of XIX and XX centuries in Cairo, moneyless and sick with tuberculosis, was trying to survive. The sign read: " I translate from any language to any language". She was a polyglot. AVI PR should be as much universal,- something like - "HEALING ANY DESEASE".
I said it before. AVI could have chosen the road that is easier travelled and concentrated on H5N1 trials. They chose the road most arduous. Why?
They know they can lick it! They are not going to the conference to show sad faces or questionable results. They are amongst peers, the very people who understand the arcane language and who live in the labs.
I would like to see good PR now.