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Calmare Therapeutics Incorporated Message Board

  • favela808 favela808 Sep 24, 2011 9:52 AM Flag

    Q and A on Calmare

    What are the various clinical indications that
    have been treated with the Calmare® Therapy
    Various types of neuropathic pain, oncologic
    visceral severe pain non-responsive to
    pharmaceutical treatment, TENS, or implanted

    ?? What are the treatment protocols for the
    various indications?
    Mixed or neuropathic pain: 10-12 consecutive
    treatments of 30 or 45 minutes; once a day, five
    days a week for two weeks.

    Oncologic Pain: initial treatment program
    consisting of I0-12 consecutive treatments of 45
    minutes once a day, and every time the pain
    recurs, future treatments as needed.
    ?? What is the average treatment protocol?
    10-12 treatments once a day for 10 days. Future
    treatments as needed.
    ?? Have there been treatment results with "no
    pain" periods of seven days, or longer?
    Yes - In most cases, after a 10-12 treatment cycle
    patients experienced reduced or no pain.

    CALMARE® Therapy Treatment is clinically proven to diminish recurrence of pain without
    the traditional side effects of drugs such as drowsiness, depression, addiction, etc.
    CALMARE® is a multiprocessor apparatus able to
    simulate five artificial neurons, allowing five separate
    pain areas to be treated simultaneously.

    ?? What is the average pain scale score for
    patient selection (Visual Analogue Scale 0-10)?
    All VAS are potentially responsive to Calmare
    Therapy Treatment, but studies focused on an
    average VAS >7 on a 0 to 10 standard scale.

    ?? What is the average result per clinical indication?
    In follow up of 10-12 treatments, the best response
    is found with neuropathic pain types. The effects of
    a treatment cycle on neuropathies can be extended
    to greater than three months. For multiple
    neuropathies the effects on a treatment cycle can
    be extended from one to three months, according
    to the damage severity.

    ?? What is the longest recorded "no pain" result
    between treatments?
    One year is the longest, however the average
    recorded "no pain" result is from 1-3 months.
    ?? What is unique about treating Cancer Pain?
    Unlike traditional TENS devices, therapy with the
    Calmare Therapy Treatment (MC-5A) device is
    effective in treating visceral oncologic pains and
    CIPN. During treatments pain may be completely
    eliminated for immediate relief, with no known side

    The type of cancer or the advanced stage of
    cancer may not allow for lengthy "no Pain" periods.
    The frequency of treatments or follow up will
    depend on specific needs of individual patients.

    What clinical indication favors longer "no pain"
    Neuropathies where tissue damage is stabilized, not
    sensitive to new inflammation or damage triggered by
    movement or other pathologies. This is often witnessed
    in sciatica where the operation is successful,
    yet the pain remains. In these cases, a complete
    treatment cycle of 10-12 treatments may completely
    relieve the pain.

    ?? What known clinical indications are not
    receptive to treatment with Calmare® Therapy
    "Not Receptive" refers to patients who do not experience
    pain relief after a treatment cycle or where
    it is not possible to localize a specific pain site. Rapid
    pain relapse after the treatment cycle occurs in an
    inflammatory causes that continuously damage the
    nervous tissue. In these cases, the therapy should be
    administered daily as the pain appears, since a single
    cycle is not sufficient to adequately treat unstable
    nervous tissue damage.

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    • ..."What are the various clinical indications..."???...I really don't see that your post answers ANY of the "driveratu" questions:

      "Just explain what exactly the electrical shocks are doing to "rewire" the brain? Why are these treatments and hour? Why once a week? Why 10 sessions? Were these times calculated? If the algorithm is so complex, it sure seems to fit with the standard calendar pretty well. What are the risks of doing the treatment EVERYDAY? Or longer than an hour? Scrambling is scrambling, right?"

      ...indeed, has anyone else tried to "rewire" a brain?...that sounds like the kind of idea that an electronics repairman might think up -- doesn't it?...

      ...indeed, why an hour?...why ten sessions?...why not just stop once the pain has been relieved?...does prolonging the therapy train the brain further?...if so, then how?...

      ...indeed, how was the algorithm arrived at? one that I know of has ever tried anything similar...what in the literature would lead Marineo to believe that a particular combination of voltages would produce a "scrambler" effect?...

      ...indeed, presuming the treatment poses no "risk" -- although several patients on the pain forums would disagree with that -- why an 45-60 minutes for 10 days? did Marineo establish that treatment beyond that would never be effective...

      ...I'll add another pertinent question -- why is the machine so expensive?...basically, it appears to be constructed like any other TENS device -- or, in the bugzapper's case, I guess it would be two devices in order to provide four leads...allegedly, the only difference lies in those marvelous "algorithms"...but they really don't look all that complicated and I'm pretty sure a $100 CPU could probably handle whatever "processing" would be necessary...EKG do much more highly complex data processing and they cost probably on average 5-6,000 dollars...what puts the bugzapper's price into the range of an ultrasound machine?...maybe CTT thought of the old joke about the salesman selling vacuum cleaners for a million bucks each -- tough but he only had to sell just one...HAW!!...

      • 1 Reply to rrtzrealmd
      • [b]Scrambler therapy differs from transcutaneous
        electrical nerve stimulation (TENS) in many aspects,
        although both provide stimulation
        via peripheral nerves.[/b] Clinically, TENS therapy
        has been shown effective in postoperative
        pain and musculoskeletal pain, but the number
        and quality of randomized controlled trials are
        often inadequate for particular conditions.
        We were not able to find any randomized trials
        of TENS for SCS or chronic postsurgical pain.

        The TENS effect in
        PHN has been limited in randomized trials
        and disappears a few hours after treatment.
        TENS provides an on-off biphasic current without
        variation, whereas Scrambler therapy provides
        continuously changing variable nonlinear
        waveforms. Recent studies with TENS units
        have used a continuous pulse pattern, pulse
        width of 200 microseconds, and a pulse frequency
        of 80 Hz, increased until the patient feels
        a strong sensation. The Scrambler therapy average
        charge per phase is 38.8 microcoulombs,
        similar to conventionalTENS devices. The phase
        duration is 6.8e10.9 microseconds, and the
        pulse rate is 43e52 Hz. Because the frequency
        delivered by the device never exceeds 52 Hz,
        the mean energy delivered per second is generally
        less than most standard TENS devices, which
        deliver a square wave with frequencies greater
        than 52 Hz.

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