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Exelixis, Inc. Message Board

  • clemcaldwell clemcaldwell Sep 20, 2013 3:58 PM Flag

    Biomarker for lung cancer.

    Mayo Clinic researchers have shown that a specific pair of proteins in smokers have potential as a biomarker for lung cancer.
    "This is exciting because we've found what we believe to be a 'drugable target' here," Mayo molecular-medicine researcher and senior study author George Vasmatzis said. "It's a clear biomarker for aggressive adenocarcinomas. These are the fast-growing cancer cells found in smokers' lungs."
    The protein ASCL1 is associated with expression of a cancer-causing gene called RET. ASCL1 is already known to affect thyroid and small-cell lung cancer development. But the link to lung cancer wasn't previously known.

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