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Exelixis, Inc. Message Board

  • wilderguide wilderguide Oct 2, 2013 8:28 PM Flag

    Gov shutdown Impact on clinical trials


    (CNN) --- 4hrs agon- Michelle Langbehn, 30, has endured nine months of chemotherapy, two cycles of radiation, a spinal fusion and several tumor removal surgeries. But the cancer that's attacking her body continues to spread, and her future treatment options are limited.
    There was hope for the Auburn, California, mom -- a clinical trial that's testing a new drug called Cabozantinib that's been approved to fight other cancers. Researchers at the National Institutes of Health had gathered Langbehn's medical records; they were set to evaluate her status on Monday to make an official enrollment decision, she says.
    Then the government shut down."

    This nonsense can't be helping anyone...

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    • Leo Finn
      For a cancer patient, the government shutdown may be a matter of life or death
      Holly Bailey, Yahoo! News Oct 3, 2013 5:11 PM
      Leo Finn was diagnosed with a rare form of bile duct cancer in February. He tried chemotherapy, but the cancer quickly spread to his liver and into his bones.

      Finn’s doctor at the Dana-Farber Cancer Institute in Boston suggested he try cabozantinib, a drug that had successfully treated thyroid cancer but had not yet been tested on other forms of cancer. The Buzzards Bay, Mass., resident and father of three had been scheduled to undergo tests this week to get the drug, as a part of a new clinical trial overseen by the National Institutes of Health. But the trial was put on hold Tuesday because of the government shutdown.

      A website operated by NIH and the Food and Drug Administration where new patients must first enroll before receiving the drug had ceased operations because of the shutdown.

      Finn is just one of potentially hundreds of patients around the country who have been turned away by NIH this week because of the shutdown. A spokeswoman for the agency estimated that about 200 patients a week enroll in current or new clinical trials held at NIH’s facility outside Washington. Thirty of those patients are children — and of those, about a third are kids suffering from cancer. And until the federal government is open again, they are all being turned away.

      Sentiment: Strong Buy

      • 2 Replies to medxwatcher
      • Cabo on cholangiocarcinoma (bile duct carcinoma)!
        what a stunning news to me! Cabo is everywhere, this amazing drug brings hope to so many cancer patients with bone mets! I am thrill to know that Cabo brings hope to cholangiocarcinoma patient with bone mets! and this news is from Dana-Farber. This amazing drug is all over the map, from US to China, from MTC to lung cancer patients with bone mets (in China). I wonder if I hold enough positions on EXEL? Shall I buy more EXEL on Monday morning?

        Sentiment: Strong Buy

      • $$$$
        Medxwatcher, thx for posting. In looking for further info based on your storyline, I found this, and I think it was posted today-

        "Beginning Friday, patients seeking experimental treatments in new clinical trials will no longer be delayed from joining those studies as a result of the government shutdown.

        The National Institutes of Health received permission Thursday to recall a handful of furloughed workers to reopen its clinical trials registration website and start processing new applications, which had stopped during the shutdown.

        Many hospitals, including Dana-Farber Cancer Institute, require patients receiving experimental drugs to be formally enrolled in a clinical trial registered on the site. Leo Finn, a Dana-Farber patient, told the Globe Wednesday that a drug he desperately needs for his metastatic bile-duct cancer would be delayed because he would not be able to join a new trial.

        Finn was contacted by his Dana-Farber physician Thursday and told that he could join the new trial and get cabozantinib — a drug approved for thyroid cancer but still experimental for other cancers — next month as planned."

        This is really good news for patients, and an interesting slant on Cabo in the news...

    • Very sad state of affairs, I hope things resolve quickly and she gets on Cabo. I think the Onion's recent point / counter-point offers some good insight to Boehner's dilemma.

      On a separate note, it's interesting that they're recommending Cabo instead of Dovitinib for fibrosarcoma. It seems the latter was custom designed to target the theoretical mechanism of fibrosarcoma proliferation.

    • They shut things down selectively. I would bet Harry Reid's and John Boehner's florists are still on the payroll. Michelle is still getting her nails done daily not to worry. That's Michelle Obama not Michelle Langbehn. That's a very sad story which doesn't reflect well on how degenerate our politics have become. Will Barack go to the funeral and lambast the Republicans? It will be poll tested and then we'll see.

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