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ZIOPHARM Oncology, Inc. Message Board

  • rob_cos rob_cos Feb 21, 2013 11:38 AM Flag

    Remember with IFOS u often need to take IV drug Mesna - you don't with Pali

    Dosage and Administration

    Prevention of Ifosfamide-Induced Hemorrhagic Cystitis
    IV Mesna dose is given as bolus injections in a dosage equal to 20% of ifosfamide dose at time of administration, 4 h after, and 8 h after each ifosfamide dose (eg, for ifosfamide 1,200 mg/m 2 , give mesna 240 mg/m 2 at 0, 4, and 8 h after each ifosfamide dose). The total daily dose of mesna is 60% of the ifosfamide dose. Repeat this dosing schedule on each day that ifosfamide is administered. When the dosage of ifosfamide is adjusted, modify the dose of mesna accordingly.

    PO Following the initial IV mesna dose (20% of ifosfamide dose), the oral mesna dose is 40% of ifosfamide dose 2 and 6 h after each ifosfamide dose.

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