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Tesaro, Inc. (TSRO) Message Board

  • favela808 favela808 May 22, 2013 10:04 AM Flag


    American Society Of Clinical Oncology Abstracts Point To Potential Profits
    May 21 2013, 10:11 | includes: BAX, BSX, CLVS, CRIS, CTTC.PK, HALO, MDT, PFE, R, SYK, TSRO, VPHM
    Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. (More...)

    The American Society of Clinical Oncology (ASCO) posted its list of abstracts to be presented at the influential Annual Meeting May 30- June 4 last week and investors have been busy going through the information. Why? It is an accepted fact that biopharmaceutical and medical device companies that have an abstract being presented on their new drug or promising medical device can experience nice returns in their stock during this time. The challenge is to parse through all the abstracts and do the due diligence required to identify the company with the drug or medical device, ascertain whether the results of a clinical study are equal to or better than expected and buy before the annual meeting convenes May 30.

    There are a number of interesting plays with this year's ASCO abstract list:

    TESARO, Inc. (TSRO) Market Capitalization: $1.16 Billion. TSRO will be presenting final results from a Phase I trial of niraparib, an inhibitor of poly ADP-ribose polymerase (PARP), on June 4, 2013-- preliminary results presented at ASCO in 2011, and support advancement of niraparib into Phase III trials. The company plans on skipping Phase II and begin enrolling patients in a Phase III trial in the ovarian cancer maintenance setting by mid-year, and to initiate a Phase III trial in patients with breast cancer during the second half of 2013 apparently based on the strong results. The stock has already reacted positively to the confirmation that TSRO had its abstract accepted for ASCO. The 52 week low is $11.05 and recently trading at $35.91. Providing a bit of potential trading drama is the short interest of 1.32 million shares (as of April 30).
    Clovis Oncology (CLVS) Market Capit

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    • Competitive Technologies (CTTC.PK) Market Capitalization:$4.88 Million. CTTC's non-invasive and non-narcotic medical device, known as Calmare, for the treatment of chronic pain, such as Chemotherapy Induced Peripheral Neuropathy (CIPN) may be mentioned in a panel discussion on "Responding to Common Concerns of Patients with Cancer: What's New-In a Nutshell-From Research to Therapeutic Strategies". Dr. Charles Loprinzi of the Mayo Clinic, one of the panelists, is involved with three (3) ongoing clinical studies on the effects of Calmare on chronic pain and recently expanded one study to include 150 patients from 100 patients--usually a good sign that the results already recorded is worthwhile enough to add patients. In an abstract on preliminary results of a study presented at ASCO last year was the "Conclusions: Scrambler therapy appears to be beneficial in the treatment of CIPN. A prospective placebo‐controlled clinical trial should be performed to confirm these preliminary findings." That clinical trial is being performed by the Mayo Clinic. What makes CTTC of particular interest is its very low market cap of only $5 Million. Medical device companies such as Boston Scientific Corporation (BSX), Stryker Corporation (SYK) and Medtronic, Inc. (MDT) could find Calmare as a good fit in their device portfolio should the company begin to see broadly accepted insurance reimbursement for the procedure.

      • 1 Reply to favela808
      • Clovis Oncology (CLVS) Market Capitalization: $969 Million. CLVS has three abstracts (ASCO Abstracts #2524, #2585, #2586) on the clinical results from three Phase I studies of the company's two lead compounds. One drug is for non-small cell lung cancer (NSCLC), in patients with initial activating EGFR mutations as well as the T790M primary resistance mutation the other promising compound is Rucaparib, an orally administered, ADP-ribose (small molecule poly) polymerase inhibitor for the treatment of ovarian cancer. The results are for the Phase I dose-escalation part of Phase I/II clinical trials. The company's stock is trading around $35.60 with a 52 week low of $11.19 As of April 30, there were 1.725 million shares shorted.

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