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Zalicus AŞ Message Board

  • chevelle_69 May 15, 2013 11:27 AM Flag

    A--Alpha Virus

    Not really news, but tired of all of Jack's posts.

    Solicitation Number:

    The United States Army Medical Research Acquisition Activity (USAMRAA) is soliciting on behalf of the United States Medical Research Institue of Infectious Disease (USAMRIID) information from potential qualified businessses. This is a non-personal services contract to provide Scientific, Technical, and Administrative Support Services. The Government shall not exercise any supervision or control over the Contract Service Providers (CSPs) performing the services herein. Such CSPs shall be accountable solely to the Contractor who, in turn, is responsible to the Government.
    Back ground and Descritption of Required Work:
    No FDA approved medical countermeasures exist to treat alphavirus infection and the development of potential therapeutics remains a high priority for the military. Currently, USAMRIID and Zalicus are funded to screen a library of FDA approved compounds for their effectiveness against encephalitic and viral hemorrhagic fever viruses. They have identified several promising candidates that warrant further characterization. However, the specific mechanism of action and in vivo effectiveness is unknown. These studies are needed as the initial steps for necessary preclinical evaluation that will lead to advanced development efforts. Therefore, the objective of this work is to further characterize and determine the mechanism of action of lead FDA approved compounds found to be effective during initial in vitro alphavirus screening efforts.