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  • scistats scistats May 18, 2013 4:12 PM Flag

    Zalicus, Z944 suppress seizures by 85 to 90%

    Sci Transl Med 15 February 2012:
    Vol. 4, Issue 121, p. 121ra19
    Sci. Transl. Med. DOI: 10.1126/scitranslmed.3003120
    T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures
    Elizabeth Tringham1, Kim L. Powell2, Stuart M. Cain3, Kristy Kuplast1, Janette Mezeyova1, Manjula Weerapura1, Cyrus Eduljee1, Xinpo Jiang1, Paula Smith1, Jerrie-Lynn Morrison1, Nigel C. Jones2, Emma Braine2, Gil Rind2, Molly Fee-Maki1, David Parker1, Hassan Pajouhesh1, Manjeet Parmar1, Terence J. O’Brien2 and Terrance P. Snutch3,*
    - Author Affiliations

    1Zalicus Pharmaceuticals Ltd., Suite 301, 2389 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.
    2Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 4th Floor, Clinical Sciences Building, Royal Parade, Parkville, Victoria 3050, Australia.
    3Michael Smith Laboratories, University of British Columbia, Room 219, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada.

    Sentiment: Strong Buy