I have bought and sold ISIS numerous times over the years, until I saw the technology work with Kynamro. After that I told my wife that in the future these shares are going to $100.00. With 30 or meds or so in the pipeline and spectacular menu of partnerships, it is as if the shares have re-launched.
Remember to take Profit - I believe the same thing, but being able to cash out my entire cost to purchase and still maintain the majority of my position allows for more flexibility when watching the price. It could fall for no reason, like it has for several months. Been watching the stock since 2007, trading it around capturing more shares as well. That bump above $28, especially after all the gains from trades riding the momentum up this year, more then covered the 80% left.
If it goes up, I win. If it comes back in I can pounce, and still win.
You do You - No one has ever been wrong for taking a profit.