We observed that:
Treatment of HIV subjects with a single infusion of SB-728-T leads to long-term increases in CD4 counts (up to 3 years in some subjects)
Long-term increases in CD4 counts correlate with increased CD4 central memory, memory stem cells (TSCM)-like and increased ZFN CCR5 protected central memory T-cells
Seven of nine subjects show decreased levels of HIV DNA at Month 12 post infusion
An inflammatory environment pre-infusion appears to be an important predictor of CD4 reconstitution post-infusion
Higher levels of inflammation correlate with poor immunological response and suggest a mechanism for altered survival of CM cells
More good news on the way:
"We look forward to presenting the results of our SB-728-902 Cohort 5 and SB-728-1101 studies in December 2013, at the Sixth International Workshop on HIV Persistence, Reservoirs and Eradication Strategies."