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Sangamo Biosciences Inc. Message Board

  • btimnextmicrosoft btimnextmicrosoft Nov 4, 2013 12:26 PM Flag

    Looks like we have a product

    We observed that:
    Treatment of HIV subjects with a single infusion of SB-728-T leads to long-term increases in CD4 counts (up to 3 years in some subjects)
    Long-term increases in CD4 counts correlate with increased CD4 central memory, memory stem cells (TSCM)-like and increased ZFN CCR5 protected central memory T-cells
    Seven of nine subjects show decreased levels of HIV DNA at Month 12 post infusion
    An inflammatory environment pre-infusion appears to be an important predictor of CD4 reconstitution post-infusion
    Higher levels of inflammation correlate with poor immunological response and suggest a mechanism for altered survival of CM cells

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