The CDC estimates, in 2007, the economic cost of diabetes was $174 billion!!!
Written by Kristi Runyon
Monday, 29 March 2010 12:17
Nearly 1/3 of people with diabetes use insulin and some people with type 2 diabetes eventually need insulin shots to control glucose levels. Researchers are testing an oral spray form of insulin to take away some of the pain of injections.
Normally, when we eat, cells in the pancreas release insulin, a hormone that enables glucose in the blood to enter cells and be used as a source of fuel. Diabetes is a disease that affects the body’s ability to use glucose. There are two main types. In type 1, the pancreas doesn’t produce insulin because of an immune system attack on the insulin-producing cells. In type 2 diabetes the pancreas either doesn’t make a sufficient amount of insulin or the body is no longer able to effectively use the hormone to get fuel into the cells.
According to the American Diabetes Association, about 23.6 million Americans have diabetes. Roughly 1.6 million new cases are diagnosed annually. Type 2 is the most common form of the disease, accounting for 90 to 95 percent of all cases.
Over time, excess glucose in the blood can damage blood vessels and organs. People with diabetes are at high risk for a number of complications, like heart disease, stroke, kidney disease, nerve damage, infections that don’t heal and amputation. The CDC estimates, in 2007, the economic cost of diabetes was $174 billion.
Insulin for Diabetes
There is no cure for diabetes. People with type 1 diabetes don’t make insulin and need regular injections of the hormone to stay alive. Patients with type 2 can often control the disease through diet, exercise, lifestyle modifications and medications. However, some of those with type 2 will eventually need insulin treatment to control glucose levels. The CDC estimates that nearly 1/3 of people with diabetes use insulin.
There are several different forms of insulin. Regular-acting insulin enters the bloodstream within 30 minutes and is effective for about 3 to 6 hours. Rapid-acting insulin gets into the blood very quickly, typically in about 5 minutes and is good for about 2 to 4 hours. Intermediate-acting insulin enters the bloodstream in 2 to 4 hours and is effective for 12 to 18 hours. Long-acting insulin takes about 6 to 10 hours to get into the bloodstream and lasts the longest, usually 20 to 24 hours.
Insulin can’t be given in a pill form because the digestive tract breaks it down before it can enter the bloodstream. Therefore, people who need insulin must take regular injections of the hormone. Some people have a hard time accepting the injections, leading to poor compliance and a greater risk for complications from diabetes.
Researchers are now testing a new way to deliver insulin, by using a mouth spray. The new form of insulin is called Oral-lyn™ and it’s delivered through a RapidMist™ device. The RapidMist is similar to an inhaler. But instead of breathing the drug into the lungs, patients hold it inside their mouth, where it is absorbed through the cheek lining. Dennis Gage, M.D., Endocrinologist with Beth Israel Medical Center in New York City, says this lining has a lot of blood vessels, enabling the drug to be quickly absorbed into the bloodstream.
GNBT was traded prety high at 2006/2007. The stock price fall down with Lilly and Pfizer competition, then fall more on Lilly and Pfizer stop thier product. But if you read the paper publised at Oco-10-2009 on <<New York Time>>, you will agree with me that about the difference between Lilly/Pfizer's product and Generex's.
Oral-lyn is now viewed as the only inhaled insulin product that is safe and effective.
Two types trial: 6 month active treatment; plus 6 month follow up.
Oral Lyn may be the first oral diabete's drug to change 84 year insulin injection history.
One trial result will be reported in July-2010, and complete at the end of 2010. A great review of clinical trials: Update on Oral insulin spray formation (PDF file), published 2010 at Diabetes,Obesity and Metabolism (link: http://www3.interscience.wiley.com/journal/122670996/abstract?CRETRY=1&SRETRY=0)
Here is two studies in Ecuador, published at Journal: <Diabetes Technol Ther> & <Diabetes Metab Res Rev>
1. Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents.
2. Oral spray insulin in treatment of type 2 diabetes: a comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study.
Yes, big difference. This is the ONLY surviving insulin spray, because it is not delivered to the lung but uptaken in the oral cavity. If they pass the FDA, their market will be gigantic. Over $170 billion worldwide. They will get a nice share of that market.