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  • backrebound backrebound Apr 15, 2010 1:23 PM Flag

    Oral Lyn on ABC news............Link
    The CDC estimates, in 2007, the economic cost of diabetes was $174 billion!!!

    Insulin Spray
    Written by Kristi Runyon
    Monday, 29 March 2010 12:17
    Nearly 1/3 of people with diabetes use insulin and some people with type 2 diabetes eventually need insulin shots to control glucose levels. Researchers are testing an oral spray form of insulin to take away some of the pain of injections.

    Normally, when we eat, cells in the pancreas release insulin, a hormone that enables glucose in the blood to enter cells and be used as a source of fuel. Diabetes is a disease that affects the body’s ability to use glucose. There are two main types. In type 1, the pancreas doesn’t produce insulin because of an immune system attack on the insulin-producing cells. In type 2 diabetes the pancreas either doesn’t make a sufficient amount of insulin or the body is no longer able to effectively use the hormone to get fuel into the cells.

    According to the American Diabetes Association, about 23.6 million Americans have diabetes. Roughly 1.6 million new cases are diagnosed annually. Type 2 is the most common form of the disease, accounting for 90 to 95 percent of all cases.

    Over time, excess glucose in the blood can damage blood vessels and organs. People with diabetes are at high risk for a number of complications, like heart disease, stroke, kidney disease, nerve damage, infections that don’t heal and amputation. The CDC estimates, in 2007, the economic cost of diabetes was $174 billion.

    Insulin for Diabetes
    There is no cure for diabetes. People with type 1 diabetes don’t make insulin and need regular injections of the hormone to stay alive. Patients with type 2 can often control the disease through diet, exercise, lifestyle modifications and medications. However, some of those with type 2 will eventually need insulin treatment to control glucose levels. The CDC estimates that nearly 1/3 of people with diabetes use insulin.

    There are several different forms of insulin. Regular-acting insulin enters the bloodstream within 30 minutes and is effective for about 3 to 6 hours. Rapid-acting insulin gets into the blood very quickly, typically in about 5 minutes and is good for about 2 to 4 hours. Intermediate-acting insulin enters the bloodstream in 2 to 4 hours and is effective for 12 to 18 hours. Long-acting insulin takes about 6 to 10 hours to get into the bloodstream and lasts the longest, usually 20 to 24 hours.

    Insulin Spray
    Insulin can’t be given in a pill form because the digestive tract breaks it down before it can enter the bloodstream. Therefore, people who need insulin must take regular injections of the hormone. Some people have a hard time accepting the injections, leading to poor compliance and a greater risk for complications from diabetes.

    Researchers are now testing a new way to deliver insulin, by using a mouth spray. The new form of insulin is called Oral-lyn™ and it’s delivered through a RapidMist™ device. The RapidMist is similar to an inhaler. But instead of breathing the drug into the lungs, patients hold it inside their mouth, where it is absorbed through the cheek lining. Dennis Gage, M.D., Endocrinologist with Beth Israel Medical Center in New York City, says this lining has a lot of blood vessels, enabling the drug to be quickly absorbed into the bloodstream.

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