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  • tla_usa tla_usa Mar 22, 2014 2:32 PM Flag

    Haemorrhagiv fever kills 29 --- SIGA arenavirus antivirus program

    Excerpts from Reuters March 22 2014
    An outbreak of haemorrhagic fever that has killed 29 people in Guinea may have spread across the border into neighbouring Sierra Leone, according to a World Health Organisation (WHO) document and a senior Sierra Leone health official.

    WHO officials..... suspect Lassa Fever may be behind the outbreak, cases of which have now also been reported in a border region in Sierra Leone, according to minutes of a March 18 teleconference seen by Reuters.

    From SIGA
    The CDC has designated several arenaviruses as Category A, indicative of the highest level of risk to public health and safety. Among these are Lassa fever, a disease with an estimated several hundred thousand cases annually in West Africa, and Argentine hemorrhagic fever, caused by Junín virus. No licensed vaccines or therapeutics are available to prevent or treat diseases caused by arenaviruses

    SIGA’s arenavirus antiviral program is supported in part by the National Institute of Allergy and Infectious Diseases through grant 1R01AI093387.

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    • Excerpts from Press Release from CDC
      For Immediate Release: Friday, April 4, 2014
      Lassa Fever Reported in U.S. Traveler Returning from West Africa

      Contact investigation under way; risk to other travelers considered extremely low

      The CDC and the Minnesota Department of Health (MDH) have confirmed a diagnosis of Lassa fever in a person returning to the United States from West Africa. The patient was admitted to a hospital in Minnesota on March 31 with symptoms of fever and confusion. Blood samples submitted to CDC tested positive for Lassa fever on April 3. The patient is recovering and is in stable condition. ((I would add that the fatality rate is about 20%))

      “This imported case is a reminder that we are all connected by international travel. A disease anywhere can appear anywhere else in the world within hours,” said CDC Director Tom Frieden, M.D., M.P.H.


      • 2 Replies to tla_usa
      • Regarding ST-161 (lassa) and ST-193
        Excerpts Via SIGA Technologies via Elsevier Ltd.:
        ST-161 ... a near tenfold increase in potency against Lassa virus pseudotypes compared to ST-193.

        Re Optimization program
        Excerpts from Abstract on ST-161
        Previously we reported the optimization of antiviral scaffolds containing benzimidazole and related heterocycles possessing activity against a variety of arenaviruses. These series of compounds were discovered through an HTS campaign of a 400,000 small molecule library using lentivirus-based pseudotypes incorporated with the Lassa virus envelope glycoprotein (LASV GP). This screening also uncovered an alternate series of very potent arenavirus inhibitors based upon an acylhydrazone scaffold. Subsequent SAR analysis of this chemical series involved various substitutions throughout the chemical framework along with assessment of the preferred stereochemistry. These studies led to an optimized analog (ST-161) possessing subnanomolar activity against LASV and submicromolar activity against a number of other viruses in the Arenaviridae family.
        ----Copyright © 2013 Elsevier Ltd.

        Excerpts from Abstract
        A series of potent arenavirus inhibitors sharing a benzimidazole core were previously reported by our group. ...... Many of the analogs containing alternate nitrogen-based bicyclic ring systems were found to retain antiviral potency compared to the benzimidazole series from which we derived our lead compound, ST-193. In fact, 21 h, built on an imidazopyridine core, possessed a near tenfold increase in potency against Lassa virus pseudotypes compared to ST-193.----Copyright © 2012 Elsevier Ltd.

      • That's easy to resolve...just don't travel to Minnesota.

        Seriously when was the last company update on any of these and other NIH programs?
        Dengue ST-610 & ST-148 Sept.12, 2008 $963,000 NIH grant
        Lassa fever and other hemorrhagic fevers of Arenavirus origin.
        August 24, 2011 $7.7 million grant from NIH.

    • What phase is drug in?

      • 1 Reply to mymygbye
      • It's been in the guinea pig phase since 2007. Earlier results showed that around 61% of the guinea pigs survived versus 0% for other treatments. Beav...Don't be such a snob. If you were a guinea pig all this would be quite important to you. Since you're a Beaver you're just kinda dissing the entire worth of this ST-193. In fact, I understand that under Obama care there is now reimbursement for guinea pigs injured by Lassa fever! So there!

    • Interesting. ..thanks for sharing tla.

    • unfortunately unless these diseases hit the west they are somewhat deemed as irrelevant. (especially if its in Africa)That's why you are the only one in the world that knows of this information. I am stuck in Siga but the beauty of owning it was it didn't sell off with the rest of the biotechs on Friday,

      • 2 Replies to siana1917
      • The following claim was first presented above as to the significance of drug development to combat Hemorrhagic fevers (Arenaariruses--Lassa) .
        "unfortunately unless these diseases hit the west they are somewhat deemed as irrelevant. (especially if its in Africa)"

        From the CDC we have this:
        Category A

        The U.S. public health system and primary healthcare providers must be prepared to address various biological agents, including pathogens

        that are rarely seen in the United States.
        High-priority agents include organisms that pose a risk to national security

        because they can be easily disseminated or transmitted from person to person; result in high mortality rates and have the potential for major public health impact;might cause public panic and social disruption; and require special action for public health preparedness.

        Anthrax (Bacillus anthracis)
        Smallpox (variola major)
        Viral hemorrhagic fevers (filoviruses [e.g., Ebola, Marburg] and arenaviruses [e.g., Lassa, Machupo])
        (and 3 others agent/diseases are also on the Catagory A threat list)

      • What phase is drug in?

2.30+0.0700(+3.14%)Aug 29 3:53 PMEDT