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Prana Biotechnology Limited Message Board

  • frobinso1 frobinso1 Apr 22, 2013 6:11 PM Flag

    Interesting recent review article mentioning PBT2

    Review Article
    Metal Dyshomeostasis and Inflammation in
    Alzheimer’s and Parkinson’s Diseases: Possible
    Impact of Environmental Exposures

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    • Abstract

      A dysregulated metal homeostasis is associated with both Alzheimer’s (AD) and Parkinson’s (PD) diseases; AD patients have decreased cortex and elevated serum copper levels along with extracellular amyloid-beta plaques containing copper, iron, and zinc. For AD, a putative hepcidin-mediated lowering of cortex copper mechanism is suggested. An age-related mild chronic inflammation and/or elevated intracellular iron can trigger hepcidin production followed by its binding to ferroportin which is the only neuronal iron exporter, thereby subjecting it to lysosomal degradation. Subsequently raised neuronal iron levels can induce translation of the ferroportin assisting and copper binding amyloid precursor protein (APP); constitutive APP transmembrane passage lowers the copper pool which is important for many enzymes. Using in silico gene expression analyses, we here show significantly decreased expression of copper-dependent enzymes in AD brain and metallothioneins were upregulated in both diseases. Although few AD exposure risk factors are known, AD-related tauopathies can result from cyanobacterial microcystin and β-methylamino-L-alanine (BMAA) intake. Several environmental exposures may represent risk factors for PD; for this disease neurodegeneration is likely to involve mitochondrial dysfunction, microglial activation, and neuroinflammation. Administration of metal chelators and anti-inflammatory agents could affect disease outcomes.

    • Just read through it while watching my dad on the baby monitor, roaming around in a fog. It's a complex puzzle to be sure, but the tools to solve it are all there. The genetic analysis available today in decoding AD is amazing. No doubt in my mind that metal dyshomeostasis is at the root of AD. PBT2 may or may not be an effective treatment, but the 'metals theory' is as solid as a rock. An iron, zinc and copper rock.

    • Thanks for the info.

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