At Cambridge Isotope lab, 1 kg of 70% deuterated water, presumably unsterile costs $377
Also read the introduction to deuteration by googling the patent for deuterated PBA compounds from 2008 which shows that deuteration is far from a sure thing in preventing a need for quinidine
maybe you can use a link below putting 3ws before the dot
The cost of producing deuterated DM is likely to rise relative to regular DM. More than modest cost of deuterated water, I'd expect increased costs to come from the slightly more involved process of making dDM and the fact that they will have fewer manufacturers to choose from who are capable of making it.
IMO, all of the above will be less important than the royalties due to Concert. I don't think the royalty levels have been released. Payments to Concert would need to be assessed relative to the royalties for CNS which would presumably drop out.
"I'd expect increased costs to come from the slightly more involved process of making dDM and the fact that they will have fewer manufacturers to choose from who are capable of making it.
IMO, all of the above will be less important than the royalties due to Concert."
Thanks, OnlyF, as always, for furthering the discussion.
I think 131 times the cost of production for deuterated dex is almost certainly going to increase the costs very significantly and interfere very significantly with margins.
It depends on how much dex itself costs. Even if dex costs only a penny per pill for Avanir to manufacture or buy, for example, then deut dex would cost about $1.31 per pill or $78.60 per month or maybe $78 per month more than dex/quin if quinidine also only cost a penny per pill.
I think this would raise the retail price by roughly $7,000 per year in order for Avanir to get a good return on its investment.
And I think it is very likely dex costs a lot more than a penny per pill.
If dex costs only five cents per pill, which seems pretty cheap to me, and if the cost is increased 131 times, deut dex would cost about $6.55 per pill ($393 per month or $4,716 per year) just for the deut dex component!
This would raise the retail cost of deut dex to probably a few thousand dollars per month or maybe $35,000 per year in order for Avanir to have a decent return on its investment.
100 ml of N-heptadecane, a simple molecule of 17 carbons saturated with single hydrogen bonds with the chemical formula C17 H36 costs $99 for 100 milliliters at Cole-Parmer.
This would be $990 for 1 liter or roughly 33.81 ounces or roughly 960.2 grams or roughly $1.03 per gram.
5 grams of deuterated N-heptadecane at Cambridge Isotope Lab costs $675 or $135 per gram.
So deuterated N-deptadecane costs 131 times regular N-heptadecane.
I seems like it is safe to say deuteration raises the price of a substance more than 100 times and probably about 131 times.
So the cost of goods sold is going to be a lot higher for deut-dex or deut-dex/quinidine than for just dex/quinidine.
I think the 131x argument is unlikely to be valid. N-heptadecane is, as far as I can tell, a specialty chemical product. Deuterated N-heptadecane is therefore a very sub-specialty chemical product (as far as I can tell) used in very small quantities. As such few will make it and the retail cost is unlikely to reflect the wholesale cost of other deuterated products made in bulk.
I'm out of my depth though...maybe someone here has specific information. Maybe Ian can get some information for us.
That's right. 30 mg of deuterated water would cost 1.13 cents, which means that 30 grams of deuterated water would cost $1.13.
One ounce is 28.35 grams. So an ounce of deuterated water would cost $1.07
How much does an ounce of bottled water cost? Is $1.50 for 128 ounces reasonable? That would be $0.012 per ounce for regular water.
So deuterated water is about one hundred times more expensive than bottled water.
Water may not be a good example because it isn't a manufactured chemical.
Let me look up something else like maybe acetic acid and I'll get back to you.