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Trius Therapeutics, AŞ Message Board

  • mikeboasberg mikeboasberg Jul 18, 2013 7:37 PM Flag

    what do u think of cempra


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    • em438 Jul 19, 2013 9:18 AM Flag

      To me solithromycin is a direct analog of tolithromycin (Ketek), which got pulled from the market due to Liver toxicity, I'm just having a hard time envisioning how by putting an aniline ring in the drug will fix the problem.
      there is a reason Aniline moieties are not found in drugs...look for yourself.
      Anyway, I'm not saying that this won't be a great pdufa play, it probably will be, I don't see any problems with phase 3 safety as even tolithromycin had a relatively clean clinical development profile. It was not until Tolith. was giving to the general public that it reared it ugly head.

    • one poster posted QUOTE this drug has a big old nasty aniline moiety on it...does anyone have any convincing data that this drug doesn't destroy the liver...heck put an aniline on a drug and you might as well throw a hand grenade in your liver. QUOTE