PubMed: Engaging the p53 metabolic brake drives senescence.
Published yesterday March 12th in the Journal of Nature:
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Emerging evidence suggests that the ability of p53 to regulate metabolism is important for its tumor suppressor activity. A recent study published in Nature reveals a novel connection between p53 and metabolism: p53 transcriptionally represses the expression of malic enzymes and associated NADPH production, which in turn triggers a positive feedback loop resulting in sustained p53 activation, cellular senescence, and tumor suppression.
The longer article which this study is based on can be found at the Journal of Natures website under Cell Research. Excellent stuff.